39003-06-0

Basic information

• Product Name: 6-chloro-N-(4-nitro-phenyl)-[1,3,5]triazine-2,4-diamine
• CAS NO: 39003-06-0
• Molecular Weight: 266.647
• Mol File: 39003-06-0.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-N-(4-nitro-phenyl)-[1,3,5]triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-N-(4-nitro-phenyl)-[1,3,5]triazine-2,4-diamine(39003-06-0)
• EPA Substance Registry System: 6-chloro-N-(4-nitro-phenyl)-[1,3,5]triazine-2,4-diamine(39003-06-0)

Safety Data

• Hazardous Substances Data: 39003-06-0(Hazardous Substances Data)

Upstream product

• 2352-36-5 4,6-dichloro-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 
• 7664-41-7 ammonia 
• 100-01-6 4-nitro-aniline 

Relevant articles and documents

Synthesis, docking, in vitro and in vivo antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives against wild and mutant malaria parasites

A new series of hybrid 4-aminoquinoline-1,3,5-triazine derivatives was synthesized by a four-step reaction. Target compounds were screened for in vitro antimalarial activity against chloroquine-sensitive (3D-7) and chloroquine-resistant (RKL-2) strains of Plasmodium falciparum. Compounds exhibited, by and large, good antimalarial activity against the resistant strain, while two of them, that is 8g and 8a, displayed higher activity against both the strains of P. falciparum. Additionally, docking study was performed on both wild (1J3I.pdb) and quadruple mutant (N51I, C59R, S108 N, I164L, 3QG2.pdb) type pf-DHFR-TS to highlight the structural features of hybrid molecules. A series of hybrid 4-aminoquinoline was synthesized and evaluated for antimalarial activity against chloroquine-sensitive (3D-7) and chloroquine-resistant (RKL-2) strains of P. falciparum.