39028-27-8

Usage

Uses

Used in Pharmaceutical Industry:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent for forming covalent bonds between proteins, which can be useful in the development of drugs and drug delivery systems.
Used in Chemical Synthesis:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a reagent for forming water-soluble carboxylate derivatives, which can be useful in various chemical synthesis processes.
Used in Research and Development:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a research tool for studying protein interactions, protein structure, and protein function due to its ability to form covalent bonds between proteins and other molecules.
Used in Biochemical Analysis:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a crosslinking agent in biochemical analysis to study the structure and function of proteins and other biomolecules.

Biological Activity

SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).

InChI:InChI=1/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 64-69-7 Iodoacetic acid 

Downstream Products

• 142182-11-4 1-(N-carbobenzyloxy-L-alanyl-L-alanyl-L-phenylalanyl)-2-iodoacetyl hydrazine 
• 221301-12-8 C₇₅H₉₉IN₂₆O₁₃ 
• 1262234-18-3 1,3,5-tris(iodoacetamidomethyl)-2,4,6-triethylbenzene 
• 1421767-20-5 C₄₂H₄₄N₅O₁₂PS₂ 
• 82339-36-4 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(iodoacetyl)-L-lysine 
• 930800-38-7 N-(hex-5-yn-1-yl)-2-iodoacetamide 
• 1208492-83-4 C₂₁H₂₉IN₄O₈ 

Relevant academic research and scientific papers

DNA-TEMPLATED MACROCYCLE LIBRARY

The present invention provides nucleic acid templates (e.g., including orthogonal codon sets (e.g., codons from orthogonal codon sets depicted in Tables 5 or 7)) for DNA-templated methods of synthesizing, selecting, and amplifying compounds (e.g., polymers and/or small molecules) described herein. Also provided are novel macrocyclic compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, libraries, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing a disease (e.g., a disease associated with aberrant enzyme activity (e.g., aberrant protease and/or kinase activity (e.g., aberrant IDE activity)), impaired insulin signaling, or insulin resistance in a subject (e.g., a subject having diabetes). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit aberrant protease activity (e.g., aberrant IDE activity).

Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry

Fluorescent coumarins are an important class of small-molecule organic fluorophores ubiquitous in different well-established and emerging fields of research including, among others, biochemistry and chemical biology. The present work aims at covering the poor detectability of coumarin-based conjugates by mass spectrometry while keeping important photophysical properties of the coumarin core. In this context, the synthesis of readily functionalizable phosphonium-tagged coumarin derivatives enabling a dual mass-tag and fluorescence labelling of analytes or (bio)molecules of interest through a single-step protocol, is reported. The utility of these coumarins is illustrated through the preparation of fluorogenic substrates that facilitated identification of the peptide fragment released by specific proteolytic cleavages.

HAPTENS AND IMMUNOREACTIVE AGENTS AND USE THEREOF FOR PRODUCING FAMILY ANTIBODIES AND IMMUNOASSAYS FOR QUINOLONES

The invention relates to haptens, immunogens and secondary immunoreactive agents, to the use thereof for producing wide-spectrum antibodies against quinolone-type antibiotics, to the application thereof to immunochemical analysis techniques, and to a kit enabling the detection of said antibiotics in biological samples from food products of animal origin.

Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1

29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.