390407-64-4

Basic information

• Product Name: 2H-1,3,2-Oxazaphosphorine, 2-chloro-3-[1,1-dimethyl-2-(phenylmethoxy)ethyl]tetrahydro-, 2-oxide
• CAS NO: 390407-64-4
• Molecular Formula: C14H21ClNO3P
• Molecular Weight: 317.752
• Mol File: 390407-64-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-1,3,2-Oxazaphosphorine, 2-chloro-3-[1,1-dimethyl-2-(phenylmethoxy)ethyl]tetrahydro-, 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,3,2-Oxazaphosphorine, 2-chloro-3-[1,1-dimethyl-2-(phenylmethoxy)ethyl]tetrahydro-, 2-oxide(390407-64-4)
• EPA Substance Registry System: 2H-1,3,2-Oxazaphosphorine, 2-chloro-3-[1,1-dimethyl-2-(phenylmethoxy)ethyl]tetrahydro-, 2-oxide(390407-64-4)

Safety Data

• Hazardous Substances Data: 390407-64-4(Hazardous Substances Data)

Upstream product

• 390407-62-2 3-(2-benzyloxy-1,1-dimethyl-ethylamino)-propan-1-ol 
• 114377-40-1 1-(benzyloxy)-2-methylpropan-2-amine 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Synthesis, in vitro metabolic studies, and antitumour activity of methyl analogues of ifosfamide

Synthesis of 2-chloro-1,1-dimethylethyl and 2-chloro-2,2-dimethylethyl analogues of ifosfamide was performed via aziridine intermediate. In vitro metabolic activation showed that both compounds are metabolised at a rate similar to the parent drug. However, their anticancer activity against L1210 leukaemia in mice was lower as compared with ifosfamide. The reduction of antitumour efficiency of examined analogues is probably caused by a lower ability to cross-link DNA by their final, active metabolites.