39051-96-2Relevant academic research and scientific papers
Synthesis and biological evaluation of cytogenin derivatives
Matsumoto,Nakashima,Isshiki,Kuboki,Hirano,Kumagai,Yoshioka,Ishizuka,Takeuchi
, p. 285 - 296 (2001)
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.
Isocoumarin derivatives and use thereof in drugs
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, (2008/06/13)
PCT No. PCT/JP96/01657 Sec. 371 Date Dec. 17, 1998 Sec. 102(e) Date Dec. 17, 1998 PCT Filed Jun. 17, 1996 PCT Pub. No. WO97/48693 PCT Pub. Date Dec. 24, 1997Compounds of the formula (I) wherein R is a hydrogen atom or a C1-6 alkyl group and n is an integer of 0 or 1, and pharmaceutical preparations thereof are provided. These pharmaceutical preparations are useful for the prevention or treatment of diseases associated with an abnormality in immunological regulatory function or vascularization.
