Journal of Antibiotics p. 285 - 296 (2001)
Update date:2022-08-04
Topics:
Matsumoto
Nakashima
Isshiki
Kuboki
Hirano
Kumagai
Yoshioka
Ishizuka
Takeuchi
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.
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