Synthesis and biological evaluation of cytogenin derivatives

DOI: 10.7164/antibiotics.54.285

Source and publish data:

Journal of Antibiotics p. 285 - 296 (2001)

Update date:2022-08-04

Topics:

Authors:

Matsumoto

Nakashima

Isshiki Isshiki

Kuboki Kuboki

Hirano Hirano

Kumagai Kumagai

Yoshioka

Ishizuka

Takeuchi

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Article abstract of DOI:10.7164/antibiotics.54.285

To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.

Full text of DOI:10.7164/antibiotics.54.285

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