39067-29-3

Basic information

• Product Name: 2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: BUTTPARK 98\12-24;2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-PYRIDIN-3-YL-THIAZOLE-4-CARBOXYLIC ACID;2-(Pyridin-3-yl)-1,3-thiazole-4-carboxylic acid;2-(3-Pyridyl)thiazole-4-carboxylic acid, 97%;4-Thiazolecarboxylicacid, 2-(3-pyridinyl)-;4-Carboxy-2-(pyridin-3-yl)-1,3-thiazole, 3-(4-Carboxy-1,3-thiazol-2-yl)pyridine
• CAS NO: 39067-29-3
• Molecular Formula: C₉H₆N₂O₂S
• Molecular Weight: 206.22
• Product Categories: Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 39067-29-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 283 °C
• Boiling Point: 460.3 °C at 760 mmHg
• Flash Point: 232.2 °C
• Appearance: /
• Density: 1.44 g/cm³
• Vapor Pressure: 2.87E-09mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: 2-8°C
• PKA: 3.29±0.10(Predicted)
• CAS DataBase Reference: 2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(39067-29-3)
• EPA Substance Registry System: 2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(39067-29-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 39067-29-3(Hazardous Substances Data)

Usage

Description

2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is a pyridylthiazole compound known for its diverse applications in various fields due to its unique chemical properties. It is characterized by its ability to form highly luminescent heterocyclic compounds, making it a promising candidate for different industries.

Uses

Used in Pharmaceutical Industry:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a potential antiulcer drug for its ability to alleviate the symptoms and complications associated with ulcers. Its chemical structure allows it to interact with the biological systems involved in ulcer formation, providing a therapeutic effect.
Used in Chemical Industry:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a key component in the formation of double and triple helicates with Cu(II). These helicates are important in the study of coordination chemistry and have potential applications in various fields, including catalysis and materials science.
Used in Material Science:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a building block for the development of mesoscopically ordered pH-responsive hybrid materials. These materials exhibit unique properties that change in response to variations in pH levels, making them suitable for applications in sensors, drug delivery systems, and other advanced technologies.
Used in Optoelectronics:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a component in the creation of highly luminescent heterocyclic compounds. These compounds have potential applications in the development of light-emitting diodes (LEDs), organic light-emitting diode (OLED) displays, and other optoelectronic devices due to their ability to emit light efficiently.

InChI:InChI=1/C9H6N2O2S/c12-9(13)7-5-14-8(11-7)6-2-1-3-10-4-6/h1-5H,(H,12,13)

Upstream product

• 4621-66-3 thionicotinamide 
• 116055-57-3 2-[3]pyridyl-thiazole-4-carboxylic acid ethyl ester; hydrobromide 
• 39067-28-2 ethyl 2-(pyridin-3-yl) thiazole-4-carboxylate 

Downstream Products

• 854399-41-0 (S)-2-{(S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-[(2-pyridin-3-yl-thiazole-4-carbonyl)-amino]-propionylamino}-3-hydroxy-propionic acid methyl ester 
• 854399-30-7 3-(tert-butyl-diphenyl-silanyloxy)-2-[(2-pyridin-3-yl-thiazole-4-carbonyl)-amino]-propionic acid 
• 1093255-54-9 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-(3-pyridinyl)-1,3-thiazole-4-carboxamide trifluoroacetate 
• 1161413-95-1 N-[2-(aminocarbonyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 
• 129799-86-6 2-methoxymethyl-1-[2-(pyridin-3-yl)thiazol-4-ylcarbonyl]-4-(3,4,5-trimethoxybenzoyl)piperazine 
• 101423-53-4 2-[1-(2,6-dichloro-benzyl)-1,4-dihydro-[3]pyridyl]-thiazole-4-carboxylic acid 

Relevant articles and documents

Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound 30m was discovered as the most active inhibitor (IC50 = 0.32 μM) with no obvious cytotoxicity (CC50 > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound 30m exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.

PYRIDINE THIAZOLE CARBOXAMIDE DERIVATIVES, THE PREPARATION METHOD THEREOF, AND THE COMPOSITION FOR SKIN WHITENING CONTAINING THE SAME

Disclosed are a pyridine thiazole carboxamide derivative expressed by a following chemistry figure 1 or pharmaceutically acceptable salt thereof, a method for preparing the same and a composition for suppressing c-kit activation or composition for skin wh