39067-29-3 Usage
Description
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is a pyridylthiazole compound known for its diverse applications in various fields due to its unique chemical properties. It is characterized by its ability to form highly luminescent heterocyclic compounds, making it a promising candidate for different industries.
Uses
Used in Pharmaceutical Industry:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a potential antiulcer drug for its ability to alleviate the symptoms and complications associated with ulcers. Its chemical structure allows it to interact with the biological systems involved in ulcer formation, providing a therapeutic effect.
Used in Chemical Industry:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a key component in the formation of double and triple helicates with Cu(II). These helicates are important in the study of coordination chemistry and have potential applications in various fields, including catalysis and materials science.
Used in Material Science:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a building block for the development of mesoscopically ordered pH-responsive hybrid materials. These materials exhibit unique properties that change in response to variations in pH levels, making them suitable for applications in sensors, drug delivery systems, and other advanced technologies.
Used in Optoelectronics:
2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is used as a component in the creation of highly luminescent heterocyclic compounds. These compounds have potential applications in the development of light-emitting diodes (LEDs), organic light-emitting diode (OLED) displays, and other optoelectronic devices due to their ability to emit light efficiently.
Check Digit Verification of cas no
The CAS Registry Mumber 39067-29-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,0,6 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 39067-29:
(7*3)+(6*9)+(5*0)+(4*6)+(3*7)+(2*2)+(1*9)=133
133 % 10 = 3
So 39067-29-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6N2O2S/c12-9(13)7-5-14-8(11-7)6-2-1-3-10-4-6/h1-5H,(H,12,13)
39067-29-3Relevant articles and documents
Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis
Liu, Mingming,Liang, Yuru,Zhu, Zhongzhen,Wang, Jin,Cheng, Xingxing,Cheng, Jiayi,Xu, Binpeng,Li, Rong,Liu, Xinhua,Wang, Yang
, p. 9299 - 9314 (2019/10/16)
In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound 30m was discovered as the most active inhibitor (IC50 = 0.32 μM) with no obvious cytotoxicity (CC50 > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound 30m exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.
PYRIDINE THIAZOLE CARBOXAMIDE DERIVATIVES, THE PREPARATION METHOD THEREOF, AND THE COMPOSITION FOR SKIN WHITENING CONTAINING THE SAME
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Page/Page column 11, (2010/11/27)
Disclosed are a pyridine thiazole carboxamide derivative expressed by a following chemistry figure 1 or pharmaceutically acceptable salt thereof, a method for preparing the same and a composition for suppressing c-kit activation or composition for skin wh