39072-28-1

Usage

Uses

Used in Pharmaceutical Industry:
2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE is used as a building block for the synthesis of bioactive molecules due to its versatile reactivity and unique structure, which allows for the creation of compounds with potential therapeutic applications.
Used in Antioxidant Applications:
2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE is used as an antioxidant agent for its ability to combat oxidative stress, which is implicated in various diseases and disorders.
Used in Antimicrobial Applications:
2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE is used as an antimicrobial agent to target and inhibit the growth of microorganisms, offering a potential solution in the fight against infections.
Used in Anticancer Applications:
2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE is used as an anticancer agent for its demonstrated potential to inhibit cancer cell growth and proliferation, contributing to the development of new cancer treatments.
Used in Medicinal Chemistry Research:
2-THIOPHEN-2-YL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE is used as a research tool in medicinal chemistry to explore its properties and reactivity, aiding in the discovery and development of new drugs for a range of diseases and disorders.

InChI:InChI=1/C14H11N3OS/c15-17-14(18)10-8-12(13-6-3-7-19-13)16-11-5-2-1-4-9(10)11/h1-8H,15H2,(H,17,18)

Upstream product

• 350997-63-6 C₁₅H₁₁NO₂S 
• 88-15-3 2-Acetylthiophene 
• 91-56-5 indole-2,3-dione 
• 31792-47-9 2-(thiophen-2-yl)quinoline-4-carboxylic acid 
• 71224-35-6 2-thiophen-2-yl-quinoline-4-carboxylic acid ethyl ester 

Downstream Products

• 39078-36-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (3-nitro-benzylidene)-hydrazide 
• 39072-18-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-nitro-benzylidene)-hydrazide 
• 39078-34-7 2-thiophen-2-yl-quinoline-4-carboxylic acid benzylidenehydrazide 
• 39072-25-8 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-methoxy-benzylidene)-hydrazide 
• 39072-27-0 2-thiophen-2-yl-quinoline-4-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-hydrazide 
• 39072-26-9 2-thiophen-2-yl-quinoline-4-carboxylic acid (4-dimethylamino-benzylidene)-hydrazide 
• 39078-35-8 2-thiophen-2-yl-quinoline-4-carboxylic acid (2-nitro-benzylidene)-hydrazide 

Relevant academic research and scientific papers

SMALL MOLECULE ENTEROVIRUS INHIBITORS AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinoline (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer) and other conditions characterized with androgen receptor activity and/or androgen receptor expression.

Convergent synthesis and cytotoxicity of novel trifluoromethyl-substituted (1H-pyrazol-1-yl)(quinolin-4-yl) methanones

A convergent synthesis of a series of 16 new polysubstituted (5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(quinolin-4-yl)methanones, starting from isatin and alky(aryl/heteroaryl) ketones, is described. The diheteroaryl methanones were achieved at yields of up to 95% by a [3?+?2] cyclocondensation reaction involving 4-alkyl(aryl/heteroaryl)-4-methoxy-1,1,1-trifluorobut-3-en-2-ones (by two-step reaction) and 2-alkyl(aryl/heteroaryl)-4-carbohydrazides (by three-step reaction). Subsequently, representative dehydrated heterocyclic derivatives were obtained from the respective 5-hydroxy-2-pyrazoline moieties by classical dehydration reactions, which resulted in the corresponding (5-(trifluoromethyl)-1H-pyrazol-1-yl)(quinolin-4-yl)methanones (three examples) at yields of 69–82%. The subsequent cytotoxicity evaluation showed that compounds with aromatic groups at the 2-position of the quinoline and a methyl moiety at the 3-position of the pyrazole have significant cytotoxicity in human leukocytes at high concentrations (200?μM).