39076-02-3

Basic information

• Product Name: methyl butan-2-ylcarbamate
• Synonyms: carbamic acid, N-(1-methylpropyl)-, methyl ester; Methyl sec-butylcarbamate
• CAS NO: 39076-02-3
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.1729
• Mol File: 39076-02-3.mol

Chemical Properties

• Melting Point: 38.5°C (estimate)
• Boiling Point: 183.8°C at 760 mmHg
• Flash Point: 65°C
• Density: 0.935g/cm³
• Vapor Pressure: 0.756mmHg at 25°C
• Refractive Index: 1.415
• CAS DataBase Reference: methyl butan-2-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl butan-2-ylcarbamate(39076-02-3)
• EPA Substance Registry System: methyl butan-2-ylcarbamate(39076-02-3)

Safety Data

• Hazardous Substances Data: 39076-02-3(Hazardous Substances Data)

Upstream product

• 33966-50-6 SEC-BUTYLAMINE 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 1113-57-1 sec-butylamide 
• 142311-89-5 N-sec-butyl carbonimidodithioic acid dimethyl ester 
• 13250-12-9 (R)-sec-butylamine 
• 513-49-5 (S)-2-aminobutane 

Downstream Products

• 3453-99-4 2,2-dimethoxybutane 

Relevant articles and documents

Conversion of carbonimidodithioates to carbamates

Carbonimidodithioates derived from primary amines or α-amino acid esters have been converted to N-benzyloxycarbonyl derivatives under mild conditions by treatment first with sodium benzyl alcoholate and then with water. N-Benzyloxycarbonyl α-amino acids have been generated from the methyl esters by alkaline hydrolysis or from the allyl esters by Pd0-catalysed de-allylation.

Aliphatic Propargylamines: Potent, Selective, Irreversible Monoamine Oxidase B Inhibitors

A series of aliphatic propargylamine derivatives has been synthesized.Some of them possess highly potent, irreversible, selective, inhibitory activity toward monoamine oxidase B (MAO-B).The potency of the inhibitors is related to chain length and substitution of a hydrogen on the terminal carbon of the aliphatic chain.MAO inhibitory activity as assessed in vitro increased as the aliphatic carbon chain length increased.Substitution of a hydrogen by hydroxyl, carboxyl, or carbethoxyl groups at the aliphatic chain terminal or replacement of the methyl group on thenitrogen atom by an ethyl group considerably reduced the inhibitory activity.Stereospecific effects were observed with the R-(-)-enantiomer being 20-fold more active than the S-(+)-enantiomer.Inhibitors with relatively short carbon chain lengths (i.e. four to six carbons) were found to be more potent than those with longer chains in inhibiting brain MAO-B activity in vivo especially after oral administration.Chronic administration of low doses of the aliphatic propargylamines caused a slight cumulative inhibition of MAO-A activity in the mouse brain.These MAO-B inhibitors appear to be nontoxic, and they do not possess an amphetamine-like moiety in their structure as is the case for deprenyl.We expect that these aliphatic propargylamines may be useful in the treatment in certain neuropsychiatric disorders.

THE HOFMANN REARRANGEMENT INDUCED BY ELECTROORGANIC METHOD

The Hofmann rearrangement has been induced by the electroorganic method using potassium bromide as a mediator, of which role in the reaction is really catalytic.