39077-35-5Relevant academic research and scientific papers
Cu(I)-catalyzed cascade reaction of N-tosylhydrazones with 3-butyn-1-ol: A new synthesis of tetrahydrofurans
Hossain, Mohammad Lokman,Wang, Kang,Ye, Fei,Zhang, Yan,Wang, Jianbo
, p. 115 - 122 (2017)
The Cu(I)-catalyzed cascade coupling/cyclization reaction of N-tosylhydrazones with 3-butyn-1-ol has been explored. This new strategy represents a simple platform for the synthesis of tetrahydrofurans in moderate to good yields.
Dehydrative condensation of carbonyls with non-acidic methylenes enabled by light: Synthesis of benzofurans
Liu, Wenbo,Chen, Ning,Yang, Xiaobo,Li, Lu,Li, Chao-Jun
, p. 13120 - 13123 (2016/11/09)
Condensation of carbonyls with non-acidic methylenes such as those adjacent to heteroatoms and allylic types to generate CC bonds is challenging but highly desirable. Inventing novel methods that can accomplish such condensations can enrich synthetic chemists' toolbox. Herein, we report a simple, clean, and high yielding protocol promoted by light to achieve condensation of non-acidic methylenes with carbonyls. As examples to demonstrate the power of this methodology, one class of ubiquitous and highly important heterocycles, i.e. benzofurans, were synthesized with broad functional group compatibility. Furthermore, intermolecular condensations were also briefly investigated.
