39091-01-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique molecular structure allows it to be a key building block in the synthesis of various drugs, particularly those targeting specific biological pathways or receptors.
Used in Drug Design and Development:
In the field of drug design and development, 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID is utilized as a starting material or a structural component in the creation of novel drug candidates. Its versatile chemical properties enable researchers to modify and optimize its structure to enhance the potency, selectivity, and pharmacokinetic properties of the resulting drug molecules.
Used in Medicinal Chemistry Research:
4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID is also employed in medicinal chemistry research to study the structure-activity relationships of various drug candidates. By investigating the effects of different structural modifications on the compound's biological activity, researchers can gain valuable insights into the design of more effective and safer pharmaceutical agents.
Used in the Development of Therapeutic Agents:
In the development of therapeutic agents, 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID serves as a valuable tool for the creation of new drugs with potential applications in treating various diseases and medical conditions. Its unique chemical structure and properties make it an attractive candidate for the development of targeted therapies, such as those for cancer, inflammatory disorders, and neurological diseases.

InChI:InChI=1/C10H8N2O2S/c1-6-8(10(13)14)15-9(12-6)7-3-2-4-11-5-7/h2-5H,1H3,(H,13,14)/p-1

Upstream product

• 98-92-0 nicotinamide 
• 4621-66-3 thionicotinamide 
• 39091-00-4 ethyl 4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylate 

Downstream Products

• 1093403-33-8 SRT₂₁₀₄ 
• 1198119-05-9 C₂₇H₂₅N₃O₃S₂ 
• 1104267-98-2 N-{[1-(4-chlorophenyl)cyclohexyl]methyl}-4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxamide 
• 1093403-43-0 4-methyl-2-pyridin-3-yl-thiazole-5-carboxylic acid [2-(3[1,2,4]triazol-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide 

Relevant academic research and scientific papers

Production method for 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice

The invention discloses a production method for synthesizing 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice through solid acid catalysis. The production method comprises the steps: taking nicotinamide as a starting material, and carrying out a reaction with P2S5 to obtain thionicotinamide; carrying out a cyclization reaction on thionicotinamide and ethyl 2-chloroacetoacetate to obtain 2-pyridyl-4-methylthiazole-5-ethyl formate; and hydrolyzing to obtain 2-pyridyl-4-methylthiazole-5-formic acid, condensing with bisabolol under the action of a solid acid catalyst, and carrying out industrial column chromatography separation to efficiently synthesize the 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice.

Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators

Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to give the thiazole derivatives (1, 2). The two ethyl thiazole-carboxylate derivatives (1, 2) thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives (5, 6) were obtained. These two derivatives (5, 6) were converted into two chloroacetamidothiadiazole derivatives (7, 8) by reaction with chloroacetylchloride over the amino group in the presence of triethylamine in acetone. After all these steps, the starting materials (7, 8) needed to reach the target compounds were obtained. With the two derivatives (7, 8) obtained in this last step, phenol and thiophenol derivatives were reacted in acetone in the presence of potassium carbonate. The target compounds, thiazolyl-thiadiazole derivatives (TDA1?16), are completely unique and their structure has been elucidated by elemental analysis, IR, NMR, and MS spectral data. After all these synthesis steps, telomerase activity studies were performed on the target compounds obtained. For this purpose, a PCR ELISA-based TRAP method was used on the heart of zebrafish. According to the enzyme assay results, derivative TDA8 has shown an increase of telomerase enzyme activity.

HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES

The present invention relates to herbicidally active pyridino-/pyrimidino-thiazole derivatives, as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising suc

Thiazoles and their use in controlling insects and pests

Certain 2-(3-pyridyl) thiazoles are useful for the control of insects, and are particularly effective against aphids. Many of these thiazoles are new compounds.