391-77-5

Basic information

• Product Name: 4-Chloro-6-fluoroquinoline
• Synonyms: BUTTPARK 20\09-07;4-CHLORO-6-FLUOROQUINOLINE;EOS-62017;4-CHLORO-6-FLUOROQUINOLINE(WX900022)
• CAS NO: 391-77-5
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.59
• Product Categories: Quinoline&Isoquinoline
• Mol File: 391-77-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 75.0 to 79.0 °C
• Boiling Point: 259.944 °C at 760 mmHg
• Flash Point: 111.011 °C
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• PKA: 2.90±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-6-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-fluoroquinoline(391-77-5)
• EPA Substance Registry System: 4-Chloro-6-fluoroquinoline(391-77-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41-37/38
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 391-77-5(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-fluoroquinoline is a chemical compound that belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, a structure characterized by a pyridine ring fused to a benzene ring. Its molecular formula is C9H5ClFNO. It typically appears as a solid, and it is known for its low toxicity. As a derivative compound of quinoline, 4-Chloro-6-fluoroquinoline can be utilized in various applications, such as in pharmaceuticals and dye production. Additionally, it may be used in the synthesis of other chemicals and compounds.

InChI:InChI=1/C9H5ClFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H

Upstream product

• 391-78-6 6-Fluoro-4-hydroxyquinoline 
• 343-10-2 6-fluoro-4-hydroxy-quinoline-3-carboxylic acid 
• 318-35-4 ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate 
• 26832-96-2 diethyl 2-(4-fluoroanilino)methylenemalonate 
• 371-40-4 4-fluoroaniline 
• 38470-26-7 6-fluoro-2,3-dihydroquinolin-4(1H)-one 

Downstream Products

• 282100-04-3 (2S)-2-[benzyl[(2R)-2-(4-benzyloxy-3-nitrophenyl)-2-hydroxyethyl]amino]-3-[4-(6-fluoroquinolin-4-yloxy)phenyl]propan-1-ol 
• 1923836-86-5 ethyl 2-(4-(6-fluoroquinolin-4-yl)cyclohex-3-en-1-yl)acetate 

Relevant articles and documents

Preparation method of 4-chloro-6-fluoroquinoline

The invention discloses a preparation method of 4-chloro-6-fluoroquinoline. The preparation method comprises the steps: with fluoroaniline as a starting material, firstly, carrying out Michael addition reaction with acrylic acid to obtain an intermediate 3-(4-fluoroanilino)propionic acid; followed by, carrying out a condensation cyclization reaction to obtain an intermediate 6-fluoro-2,3-dihydroquinoline-4(1H)-one; and finally, carrying out halogenation and dehydrogenation reaction to obtain 4-chloro-6-fluoroquinoline. The preparation method has the advantages of wide raw material sources and relatively low cost, thereby having relatively low production cost; at the same time, the preparation method has the advantages of relatively short synthesis route and relatively high yield, especially has mild reaction conditions, has no need of special high temperature equipment, and is suitable for industrialized mass production.

7-Hydroxy-benzo[ij]quinolizine-2-carboxylic acids, intermediates, and a method for their production

Intermediates for and a process for preparing certain substituted 6,7-dihydro-7-hydroxy-1-oxo-1H,5H-benzo[ij]quinolizine carboxylic acids is described. The end products are useful antibacterial agents.