39113-02-5

Upstream product

• 39191-76-9 ethyl 2-(2-(bromomethyl)phenyl)acetate 
• 13737-37-6 methyl 2-[2-(bromomethyl)phenyl]acetate 
• 13737-35-4 o-(bromomethyl)phenylacetic acid 
• 644-36-0 o-methylphenylacetic acid 

Downstream Products

• 38546-07-5 3-[(3-oxo-3,4-dihydro-1H-isoquinolin-2-ylimino)-methyl]-rifamycin 
• 39113-05-8 2-{[1-Phenyl-meth-(Z)-ylidene]-amino}-1,4-dihydro-2H-isoquinolin-3-one 
• 39113-15-0 N-(3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)benzamide 
• 39113-25-2 2-(N'-phenylureido)-1,4-dihydroisoquinolin-3(2H)-one 
• 39113-16-1 N-(3-Oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetamide 
• 39113-20-7 N-(3-Oxo-3,4-dihydro-1H-isoquinolin-2-yl)-benzenesulfonamide 
• 39113-18-3 3,4-Dichloro-N-(3-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-benzamide 
• 39113-07-0 2-{[1-(3,4-Dichloro-phenyl)-meth-(Z)-ylidene]-amino}-1,4-dihydro-2H-isoquinolin-3-one 
• 39113-24-1 2-ureido-1,4-dihydroisoquinolin-3(2H)-one 

Relevant academic research and scientific papers

Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (E.C. 3.4.11.1), aminopeptidase-N (E.C. 3.4.11.2), Aeromonas proteolytica aminopeptidase (E.C. 3.4.11.10), and the aminopeptidase activity of leukotriene A4 hydrolase (E.C. 3.3.2.6). Several compounds showed Ki values in the low micromolar range against the 'one-zinc' aminopeptidases, while most of them were rather poor inhibitors of the 'two-zinc' enzymes. This interesting selectivity profile may guide the design of new, specific inhibitors of target mammalian aminopeptidases with one active site zinc.