39117-96-9Relevant academic research and scientific papers
Lower rim 1,3-diderivative of calix[4]arene-appended salicylidene imine (H2L): Experimental and computational studies of the selective recognition of H2L toward Zn2+ and sensing phosphate and amino acid by [ZnL]
Joseph, Roymon,Chinta, Jugun Prakash,Rao, Chebrolu P.
experimental part, p. 3387 - 3395 (2010/08/03)
A new 1,3-diderivative of calix[4]arene appended with hydroxymethyl salicylyl imine has been synthesized and its ion recognition toward biologically relevant Mn+ ions studied. The receptor H2L showed selectivity toward Zn2+/sup
Studies on enzyme-cleavable dialkoxymethyl-cycloSaligenyl-2′, 3′-dideoxy-2′,3′-didehydrothymidine monophosphates
Gisch, Nicolas,Balzarini, Jan,Meier, Chris
experimental part, p. 6752 - 6760 (2009/11/30)
Recently we reported on conceptually new enzymatically activated cycloSal-pronucleotides. Now, we developed this concept further with new compounds of this type. The basic idea is fast intracellular cleavage of a functionalized group at the cycloSal residue that results in a rapid delivery of the nucleotide and thus an intracellular enrichment of the nucleotide. The introduction of a higher alkylated acylal group, the di-iso-butyryloxymethyl group, to the aromatic ring led to the expected higher stability of these prodrugs against enzymatic cleavage but also entailed surprisingly a decrease in hydrolysis stabilities and solubility problems. For some compounds, a separation of the two diastereomeric forms (RP or SP) was achieved. By X-ray structure analysis, the absolute configuration at the P-atom was assigned. For all separated diastereomers the (SP) form showed better antiviral activity than the (RP) form.
Synthesis and conformational aspects of 20- and 40-membered macrocyclic mono and dinuclear uranyl complexes incorporating salen and (R)-BINOL units
Amato, Maria E.,Ballistreri, Francesco P.,Pappalardo, Andrea,Sciotto, Domenico,Tomaselli, Gaetano A.,Toscano, Rosa Maria
, p. 9751 - 9757 (2008/02/13)
20- and 40-membered macrocyclic mono and dinuclear uranyl complexes 11-13 incorporating salen and (R)-BINOL units have been designed and synthesized starting from 4-tert-butylphenol in eight steps. NMR measurements (COSY, NOESY/EXSY) indicate that such co
