391198-86-0Relevant academic research and scientific papers
Simple and efficient routes for the preparation of isoxazolidinyl nucleosides containing cytosine and 5-methyl-cytosine as new potential anti-HIV drugs
Colacino, Evelina,Converso, Antonella,Liguori, Angelo,Napoli, Anna,Siciliano, Carlo,Sindona, Giovanni
, p. 8551 - 8557 (2007/10/03)
A rapid and convenient large-scale strategy for the synthesis of some new isoxazolidinyl nucleosides, as potential antiviral drugs, is reported. In particular, a multistep methodology based either on the 1,3-dipolar cycloaddition approach or on a slight modification of the convertible nucleoside concept was exploited in the preparation of 4′-aza-2′,3′-dideoxynucleoside analogues containing cytosine and 5-methyl-cytosine.
