391212-52-5

Basic information

• Product Name: Benzamide, N-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-3,4-difluoro-2-[(2-fluor o-4-iodophenyl)amino]-
• CAS NO: 391212-52-5
• Molecular Formula: C19H18F3IN2O4
• Molecular Weight: 522.263
• Mol File: 391212-52-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-3,4-difluoro-2-[(2-fluor o-4-iodophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-3,4-difluoro-2-[(2-fluor o-4-iodophenyl)amino]-(391212-52-5)
• EPA Substance Registry System: Benzamide, N-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-3,4-difluoro-2-[(2-fluor o-4-iodophenyl)amino]-(391212-52-5)

Safety Data

• Hazardous Substances Data: 391212-52-5(Hazardous Substances Data)

Upstream product

• 391211-97-5 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid 
• 120564-14-9 (4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxyamine 
• 1499-21-4 Diphenylphosphinic chloride 
• 76679-39-5 [(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate 
• 131068-34-3 (R)-2-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-isoindole-1,3-dione 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 29632-74-4 2-fluro-4-iodoaniline 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 833451-96-0 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl chloride 

Downstream Products

• 391210-10-9 PD0325901 

Relevant articles and documents

Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof

The present disclosure relates to a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof, and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

METHODS OF PREPARING MEK INHIBITOR

This invention relates to methods of preparing MEK inhibitor N-[(R)-2,3-dihydroxy-propoxy]-3,4- difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide that useful for treating diseases mediated by MEK activity in mammals. The present invention provides new synthetic routes that are safe, efficient and cost effective when carried out on a commercial scale.

Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids

The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.