833451-96-0

Basic information

• Product Name: Benzoyl chloride, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
• Synonyms: Benzoyl chloride,3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino];3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoyl chloride
• CAS NO: 833451-96-0
• Molecular Formula: C13H6ClF3INO
• Molecular Weight: 411.549
• Mol File: 833451-96-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-(833451-96-0)
• EPA Substance Registry System: Benzoyl chloride, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-(833451-96-0)

Safety Data

• Hazardous Substances Data: 833451-96-0(Hazardous Substances Data)

Upstream product

• 391211-97-5 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid 
• 29632-74-4 2-fluro-4-iodoaniline 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 934660-67-0 1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl]-3-azetidinone 
• 568599-53-1 methyl 3,4-difluoro-2-(2′-fluoro-4′-iodophenylamino)benzoate 
• 934665-56-2 tert-butyl (S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}perhydropyridine-1-carboxylate 
• 391212-52-5 N-{[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide 

Relevant articles and documents

Structure activity relationships of anthranilic acid-based compounds on cellular and in vivo mitogen activated protein kinase-5 signaling pathways

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METHODS OF PREPARING MEK INHIBITOR

This invention relates to methods of preparing MEK inhibitor N-[(R)-2,3-dihydroxy-propoxy]-3,4- difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide that useful for treating diseases mediated by MEK activity in mammals. The present invention provides new synthetic routes that are safe, efficient and cost effective when carried out on a commercial scale.