833451-96-0

Upstream product

• 391211-97-5 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 29632-74-4 2-fluro-4-iodoaniline 

Downstream Products

• 934665-56-2 tert-butyl (S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}perhydropyridine-1-carboxylate 
• 568599-53-1 methyl 3,4-difluoro-2-(2′-fluoro-4′-iodophenylamino)benzoate 
• 934660-67-0 1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl]-3-azetidinone 
• 391212-52-5 N-{[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide 

Relevant academic research and scientific papers

NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF

Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEKI/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.

METHODS OF PREPARING MEK INHIBITOR

This invention relates to methods of preparing MEK inhibitor N-[(R)-2,3-dihydroxy-propoxy]-3,4- difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide that useful for treating diseases mediated by MEK activity in mammals. The present invention provides new synthetic routes that are safe, efficient and cost effective when carried out on a commercial scale.

DIPHENYLAMINO KETONE DERIVATIVES AS MEK INHIBITORS

The present invention relates to diphenylamino ketone derivatives, pharmaceutical compositions and methods of use thereof.