391218-47-6

Basic information

• Product Name: C₂₀H₁₂ClN₃O₄S
• Synonyms: C₂₀H₁₂ClN₃O₄S
• CAS NO: 391218-47-6
• Molecular Weight: 425.852
• Mol File: 391218-47-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₂ClN₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₂ClN₃O₄S(391218-47-6)
• EPA Substance Registry System: C₂₀H₁₂ClN₃O₄S(391218-47-6)

Safety Data

• Hazardous Substances Data: 391218-47-6(Hazardous Substances Data)

Upstream product

• 30616-38-7 4-amino-2-benzothiazol-2-yl-phenol 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 

Relevant articles and documents

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT)

We previously reported the discovery of the activity of chloronitrobenzamides (CNBs) against bloodstream forms of Trypanosoma brucei. Herein we disclose extensive structure-activity relationship and structure-property relationship studies aimed at identification of tractable early leads for clinical development. These studies revealed a promising lead compound, 17b, that exhibited nanomolar potency against T. brucei (EC 50 = 27 nM for T. b. brucei, 7 nM for T. b. rhodesiense, and 2 nM for T. b. gambiense) with excellent selectivity for parasite cells relative to mammalian cell lines (EC50 > 25 μM). In addition compound 17b displayed suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to justify pursuing in vivo studies.