39142-41-1

Upstream product

• 96-50-4 2-thiazolylamine 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 37663-61-9 2-benzylsulfanyl-thiazolo[3,2-a][1,3,5]triazin-4-one 
• 41227-91-2 1-Aethoxycarbonyl-3-(2-thiazolyl)-harnstoff 
• 19958-82-8 N-(thiazol-2-yl)thiourea 
• 41228-13-1 1(H)-Aethoxycarbonyl-2-propargyl-3-(2-thiazolyl)isothioharnstoff 
• 41228-16-4 N¹-thiazol-2-yl-1,μ-diimido-1-thio-dicarbonic acid S-benzyl ester O-ethyl ester 
• 41228-17-5 [benzylsulfanyl-(3-benzyl-3H-thiazol-2-ylideneamino)-methylene]-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-aminothiazole scaffold

A series of new thiourea derivatives of 1,3-thiazole have been synthesized. All obtained compounds were tested in vitro against a number of microorganisms, including Gram-positive cocci, Gram-negative rods and Candida albicans . Compounds were also tested for their in vitro tuberculostatic activity against the Mycobacterium tuberculosis H37Rv strain, as well as two 'wild' strains isolated from tuberculosis patients. Compounds 3 and 9 showed significant inhibition against Gram-positive cocci (standard strains and hospital strain). The range of MIC values is 2-32 μg/mL. Products 3 and 9 effectively inhibited the biofilm formation of both methicillin-resistant and standard strains of S. epidermidis. The halogen atom, especially at the 3rd position of the phenyl group, is significantly important for this antimicrobial activity. Moreover, all obtained compounds resulted in cytotoxicity and antiviral activity on a large set of DNA and RNA viruses, including Human Immunodeficiency Virus type 1 (HIV-1) and other several important human pathogens. Compound 4 showed activity against HIV-1 and Coxsackievirus type B5. Seven compounds resulted in cytotoxicity against MT-4 cells (CC5010 μM).

Efficient and novel synthesis of N-Aryl-N'-ethoxycarbonylthiourea and arene-bis-ethoxycarbonylthiourea derivatives catalyzed by TMEDA

A series of N-aryl-N'-ethoxycarbonyl thioureas and arene-bis- ethoxycarbonylthiourea derivatives have been synthesized in good to excellent yields under the TMEDA catalyzed conditions at room temperature.

Microwave promoted efficient synthesis of N-aryl-N′-ethoxycarbonyl thioureas under solvent-free and phase-transfer catalysis conditions

A series of N-aryl-N′-ethoxycarbonyl thioureas 3a-j were synthesised under microwave irradiation, phase transfer catalysis and solvent-free conditions.