39142-48-8Relevant academic research and scientific papers
Preparation process of alkoxycarbonyl thiourea
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Paragraph 0026-0028, (2021/01/24)
The invention relates to a preparation process of alkoxycarbonyl thiourea. The process comprises the following steps: 1, preparing alkoxycarbonyl isothiocyanate by using chloroformate and thiocyanateas raw materials; and 2, adding an aqueous solution of an amine compound to the bottom of a reaction kettle, slowly dropwise adding the alkoxycarbonyl isothiocyanate prepared in the step 1, controlling the dropwise adding temperature at 0-50 DEG C, continuously heating to 60-90 DEG C after the dropwise adding is completed, and standing for layering to obtain an organic phase product. According tothe preparation process of the alkoxycarbonyl thiourea, the feeding mode is changed, and production operation control is better facilitated; the heat release rate of the alkoxycarbonyl thiourea synthesis reaction is favorably reduced; safe production is facilitated; and no flammable and explosive organic solvent with high cost and large pollution is used. The process is simple to operate, and is more beneficial to industrial production control operation, so that safe production of the alkoxycarbonyl thiourea is realized.
INDOLYLALKYLAMINO-METHYLIDENECARBAMATE DERIVATIVES USEFUL AS GNRH ANTAGONISTS
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Page 33, (2008/06/13)
The invention relates to a group of novel indole compounds of Formula (I): wherein: R1, R2, R4, R6, R6a, R7, R8, R9, R10, and A are as defined in the specif
