39143-74-3Relevant academic research and scientific papers
AlCl3-catalyzed insertion of isocyanides into nitrogen-sulfur bonds of sulfenamides
Shiro, Daisuke,Fujiwara, Shin-Ichi,Tsuda, Susumu,Iwasaki, Takanori,Kuniyasu, Hitoshi,Kambe, Nobuaki
, p. 1531 - 1534 (2015/03/14)
Lewis acid-catalyzed insertion of isocyanides 2 into nitrogen-sulfur bonds of sulfenamides 1 was developed. This method provided a convenient method for the synthesis of isothioureas 3. Among Lewis acids examined, AlCl3 brought about the best result. Acetic acid assisted one-pot preparation of unsymmetrical ureas was also described.
Antidepressant activity of carbamates and urea derivatives
Perveen, Shahnaz,Fatima, Nasreen,Khan, Muhammad Aitmaud,Dar, Ahsana,Khan, Khalid M.,Afza, Nighat,Voelter, Wolfgang
, p. 2709 - 2715 (2012/11/06)
Thirteen (13) compounds of N-phenyl-O-alkyl carbamates (1 and 3), N,N-diethyl-N′-alkyl/aryl/phenylpiperazinoureas (4-6, 8-12), N-phenyl-N′-phenylpiperazino/imidazoureas (2, 7), and N-ethyl-(N′- phenylpiperazino) thioureas 13 were synthesized and tested for their antidepressant-like activity in mice. It was found that compound N-phenyl-O-heptyl carbamate 1 and N-phenyl-N′-phenylpiperazinourea 2 showed 32.5 and 27.7% antidepressant activity in the forced swim test in mice, respectively. Considering other carbamates it was found that a decrease in alkyl chain length caused a marked decline in the antidepressant activity. Compounds 1-4 show even higher activities in the forced swim test than the standard phenelzine. Springer Science+Business Media, LLC 2011.
