39145-43-2

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 1552-96-1 4-dimethylaminocinnamic acid 

Downstream Products

• 74675-95-9 3-(4-dimethylamino-phenyl)-N-(5-nitro-thiazol-2-yl)-acrylamide 
• 866404-56-0 2'-chloroethyl 4-dimethylaminocinnamate 
• 74675-94-8 3-(4-dimethylamino-phenyl)-N-(4-phenyl-thiazol-2-yl)-acrylamide 
• 1065478-33-2 methyl 2-{2-[4-(dimethylamino)cinnamoyl]amino-1-oxo-3-phenyl}propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate 
• 1065478-21-8 C₃₁H₃₈N₄O₅ 
• 65075-85-6 4-{5-[2-(4-methoxy-phenyl)-oxazolo[4,5-b]phenoxazin-5-yl]-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl}-N,N-dimethyl-aniline 
• 65075-75-4 1-acetyl-5-(4-dimethylamino-phenyl)-3-[2-(4-methoxy-phenyl)-oxazolo[4,5-b]phenoxazin-5-yl]-4,5-dihydro-1H-pyrazole 
• 65075-84-5 N,N-dimethyl-4-[1-phenyl-3-(2-phenyl-oxazolo[4,5-b]phenoxazin-5-yl)-4,5-dihydro-1H-pyrazol-5-yl]-aniline 
• 65075-74-3 1-acetyl-5-(4-dimethylamino-phenyl)-3-(2-phenyl-oxazolo[4,5-b]phenoxazin-5-yl)-4,5-dihydro-1H-pyrazole 
• 65075-95-8 4-{3-[2-(4-methoxy-phenyl)-oxazolo[4,5-b]phenoxazin-5-yl]-4,5-dihydro-isoxazol-5-yl}-N,N-dimethyl-aniline 
• 65075-94-7 N,N-dimethyl-3-[3-(2-phenyl-oxazolo[4,5-b]phenoxazin-5-yl)-4,5-dihydro-isoxazol-5-yl]-aniline 
• 65075-66-3 5-[3t-(4-dimethylamino-phenyl)-acryloyl]-2-(4-methoxy-phenyl)-5H-oxazolo[4,5-b]phenoxazine 
• 66062-08-6 4-(4-dimethylamino-phenyl)-6-naphtho[1,2-d]oxazol-2-yl-3-phenyl-3,4-dihydro-1H-pyrimidine-2-thione 
• 66061-63-0 N,N-dimethyl-4-(5-naphtho[1,2-d]oxazol-2-yl-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline 

Relevant academic research and scientific papers

N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators has not been fully elucidated. N-Cinnamoylanthranilic acid derivatives (CADs) contain structural elements from the TRPA1 modulators cinnamaldehyde and flufenamic acid, so it was hypothesized that specific modulators could be found amongst them and more could be learnt about modulation of TRPA1 with these compounds. A series of CADs was therefore screened for agonism and antagonism in HEK293 cells stably transfected with WT-human (h)TRPA1, or C621A, F909A or F944A mutant hTRPA1. Derivatives with electron-withdrawing and/or electron-donating substituents were found to possess different activities. CADs with inductive electron-withdrawing groups were agonists with desensitising effects, and CADs with electron-donating groups were either partial agonists or antagonists. Site-directed mutagenesis revealed that the CADs do not undergo conjugate addition reaction with TRPA1, and that F944 is a key residue involved in the non-covalent modulation of TRPA1 by CADs, as well as many other structurally distinct non-reactive TRPA1 ligands already reported.

Synthesis and biological evaluation of N-cinnamoyl and mandelate metformin analogues

A series of N,N-dimethyl-N1-[3-(substituted phenyl)-1-oxo-2-propenyl]biguanides were synthesized by coupling a solution of metformin in pyridine with different cinnamoyl chloride derivatives in ether for 3 h in addition to synthesis of some five molecules of metformin-mandelates. All the synthesized cinnamoyl metformins and a few metformin-mandelates were characterized by IR, NMR and Mass spectroscopic techniques. All the synthesized compounds were also evaluated for their antioxidant activity by DPPH scavenging method and nitric oxide scavenging method. All the compounds exhibited good antioxidant activity.

Design, synthesis and cytotoxic evaluation of novel imatinib amide derivatives that target Abl kinase

Novel imatinib amide derivatives (a1-28, b1-9) were synthesized and evaluated for their biological activities. All compounds were characterized by 1H NMR, MS and elemental analysis. Among all the derivatives, compounds a4, a10, a21, b1 and b2 displayed the most significant ability of inhibiting K562 cell proliferation with the IC50 values of 0.67, 0.66, 0.65, 0.59 and 0.62 μM, respectively, indicating that these compounds were potent inhibitors of Bcr-Abl in leukemic K562 cells, comparable to the reference compound imatinib. Molecular docking study was performed to position compounds a21 and b1 into the active site of Abl to determine the probable binding modes

Polyamides containing extended pendant groups of dimethylaminocinnamate type

Functionalization of polyamides is an attractive route for improving their properties and render them suitable for specific applications. A new series of polyamides containing dimethylaminocinnamate chromophores, as pendant groups, are synthesized by dire