39157-03-4Relevant academic research and scientific papers
Syntheses and structure-activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
Wang, Bo,Liu, Yang,Wang, Yanshi,Liu, Xin,Cheng, Mao-Sheng
, p. 7110 - 7113 (2012)
Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.
PHENOLIC COMPOUND AND RECORDING MATERIAL
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Page/Page column 11, (2012/01/03)
Provided is a recording material with a superior storage property for the background and image, particularly with a remarkable superiority in any of light resistance of the background, and light, moisture and heat resistance of the image. The recording ma
Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells
Chang, Sheng,Yin, Shi-Liang,Wang, Jian,Jing, Yong-Kui,Dong, Jin-Hua
experimental part, p. 4166 - 4179 (2009/12/28)
A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2- ylamino)phenyl]acrylamide( 12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.
