39157-07-8

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 949-98-4 2-methyl-3-(4-nitrophenyl)acrylic acid 

Downstream Products

• 1598408-56-0 C₁₁H₁₄N₂O 
• 1598408-57-1 C₁₈H₂₀N₂O 
• 1598408-58-2 C₁₆H₂₂N₂O₂ 
• 1598408-35-5 1-(4-((E)-2-(methylcarbamoyl)propen-1-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1598408-36-6 1-(4-((E)-2-(1-phenylethylcarbamoyl)propen-1-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1598408-37-7 1-(4-((E)-2-(2,6-dimethylmorpholinocarbamoyl)propen-1-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 76691-30-0 (E)-2-Methyl-3-(4-nitro-phenyl)-1-(4-phenyl-piperazin-1-yl)-propenone 
• 1361029-59-5 2,9-dimethyl-1-(4-nitrophenyl)-3H-pyrrolo[1,2-a]indol-3-one 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 93130-72-4 phenyl α-methyl-(p-guanidinophenyl)propionate methanesulfonate 
• 93130-52-0 phenyl α-methyl-p-guanidinocinnamate methanesulfonate 
• 93130-93-9 phenyl α-methyl-p-aminocinnamate methanesulfonate 
• 76691-34-4 (E)-N-Isopropyl-2-methyl-3-(4-nitro-phenyl)-acrylamide 
• 76691-32-2 (E)-2-Methyl-1-morpholin-4-yl-3-(4-nitro-phenyl)-propenone 

Relevant academic research and scientific papers

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.

Aerobic palladium(II)-catalyzed 5-endo-trig cyclization: An entry into the diastereoselective C-2 alkenylation of indoles with tri- and tetrasubstituted double bonds

The endo trick: An endo ring closure onto the trigonal β carbon atom of α,β-unsaturated acceptors that are tethered to the indole nitrogen atom followed by amide cleavage enables the diastereoselective C-2 alkenylation of indoles with fully substituted double bonds. The carboxy group functions as a synthetically useful temporary tether (see scheme). Copyright

Carboxamide compounds as SRS-A antagonists

The compounds of the invention are certain new propenamides and 2-butenamides having a (carboxyalkanamido)phenyl or a (carboxyalkenamido)phenyl group at the 3-position, and certain esters thereof, and certain cyclopropanecarboxamide compounds having a (ca

Carboxamide compounds as SRS-A antagonists

The compounds of the invention are certain new propenamide and 2-butenamide compounds, having a (4-carboxy-2-oxo-pyrrolidino)phenyl substituent at the 3-position, and certain esters thereof, and certain cyclopropanecarboxamide compounds, having a (4-carbo

(Carboxy-oxo-pyrrolidino)phenylalkenamides and esters thereof as SRS-A antagonists

Certain new propenamide and 2-butenamide compounds, having a (4-carboxy-2-oxo-pyrrolidino)phenyl substituent at the 3-position, and certain esters thereof, and their use for antagonizing the spasmogenic activity of slow-reacting substance of anaphylaxis (

(Carboxyacylamino)phenylalkenamides and esters thereof as SRS-A antagonists

Certain new propenamides and 2-butenamides having a (carboxyalkanamido)phenyl or a (carboxyalkenamido)phenyl group at the 3-position, and certain esters thereof, and their use for antagonizing the spasmogenic activity of slow-reacting substance of anaphyl

AMINO- OR GUANIDINO-PHENYLPROPIONIC ACID DERIVATIVES

Amino-or guanidino-phenylpropionic ester derivatives represented by the formula: STR1 wherein R is--NH 2 or STR2 R 1 is hydrogen or a lower alkyl group, and R 2 is an unsubstituted or a lower-alkyl-, carboxyalkyl-, lower-alkoxy-, lower-alkoxycarbonyl-or h