3916-78-7

Basic information

• Product Name: 6-CHLOROPYRIDAZINE-3-THIOL
• Synonyms: 6-Chloro-3(2H)-pyridazinethione;3-pyridazinethiol, 6-chloro-;3(2H)-Pyridazinethione, 6-chloro-;6-Chloro-3-pyridazinethiol;Nsc75790;3-Chloro-6-mercaptopyridazine;6-chloro-2H-pyridazine-3-thione
• CAS NO: 3916-78-7
• Molecular Formula: C4H3ClN2S
• Molecular Weight: 146.6
• EINECS: 200-001-2
• Mol File: 3916-78-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 136-138 °C
• Boiling Point: 220.4°Cat760mmHg
• Flash Point: 87.1°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: 1.689
• PKA: 7.06±0.40(Predicted)
• CAS DataBase Reference: 6-CHLOROPYRIDAZINE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROPYRIDAZINE-3-THIOL(3916-78-7)
• EPA Substance Registry System: 6-CHLOROPYRIDAZINE-3-THIOL(3916-78-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3916-78-7(Hazardous Substances Data)

Usage

General Description

6-Chloropyridazine-3-thiol, also known as 6-chloro-3-pyridazinethiol, is classified as an organoclorine compound and a member of pyridazines. This chemical is particularly significant in the field of organic chemistry. Its molecular structure consists of a six-membered aromatic ring, similar to benzene, but two of the carbon atoms have been replaced by nitrogen atoms. It has chlorine (-Cl) and thiol (-SH) functional groups attached, which significantly influence its chemical behavior. Information about its uses, properties, hazards or toxicity is limited; further studies are required to understand this chemical fully. As with all chemicals, proper handling and safety measures should be observed.

InChI:InChI=1/C4H3ClN2S/c5-3-1-2-4(8)7-6-3/h1-2H,(H,7,8)

Upstream product

• 141-30-0 3,6-dichlorpyridazine 

Downstream Products

• 7145-61-1 3-chloro-6-(methylsulfanyl)pyridazine 
• 88538-48-1 3-chloro-pyridazine-6-sulphonamide 
• 17284-97-8 3-Chloro-6-hydrazinopyridazine 

Relevant articles and documents

Synthesis of water-soluble pyridazine derivative and application thereof

The invention discloses synthesis and an application of a water-soluble pyridazine derivative, belongs to the technical field of synthesis and an application of a water-soluble pyridazine derivative corrosion inhibitor, and particularly relates to synthesis of a water-soluble heterocyclic corrosion inhibitor containing two nitrogen atoms and an application of the water-soluble heterocyclic corrosion inhibitor to corrosion inhibition of copper in a sulfuric acid solution with the concentration of 0.5 mol/L. The metallic copper and alloy thereof are widely applied to industries such as electrical industry, mechanical industry, traffic industry, ship industry and the like, but the copper is also subjected to serious corrosion in an acidic or marine environment. At present, the use of an organic corrosion inhibitor is one of the most effective ways for inhibiting the corrosion of copper. Although an existing heterocyclic organic corrosion inhibitor containing atoms such as nitrogen, oxygen, phosphorus and sulfur has a certain corrosion inhibition effect on copper in a sulfuric acid solution, most organic matters in the heterocyclic organic corrosion inhibitor are poor in water solubility and low in corrosion inhibition efficiency. In order to overcome the defects in the prior art, the water-soluble pyridazine derivative containing multiple heteroatoms is synthesized and serves as a corrosion inhibitor of metal copper in a sulfuric acid solution with the concentration of 0.5 mol/L.

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to sulfonyl compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.