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Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 1063600-20-3 6-trifluoromethyl-4-(triisopropylsilyl)methyl-2-(o-nitrophenyl)quinoline 
• 1134638-22-4 C₁₉H₁₉F₃N₂O₂ 
• 1373546-79-2 4,4-dimethyl-2-(2-nitrophenyl)-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline 
• 1373545-22-2 N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide 
• 1373545-24-4 N-[2-(4,4-Dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-2-fluoro-benzenesulfonamide 
• 1373545-26-6 N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-4-fluoro-benzenesulfonamide 
• 1373545-28-8 ethanesulfonic acid [2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide 
• 1373545-30-2 N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide 
• 1373545-32-4 N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-methanesulfonamide 
• 1373545-46-0 pyridine-3-sulfonic acid N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide 
• 1373546-81-6 2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline 
• 501917-68-6 2-(4-(trifluoromethyl)phenyl)–2H-indazole 

Relevant academic research and scientific papers

Manganese-Catalyzed Electrochemical Tandem Azidation-Coarctate Reaction: Easy Access to 2-Azo-benzonitriles

A one-pot cascade transformation consisting of an electrochemically driven azidation of 2H-indazole followed by coarctate fragmentation is developed to synthesize the 2-azo-benzonitrile motif. This manganese-catalyzed transformation is external-chemical-oxidant-free and operates at ambient temperature under air. This methodology exhibits good functional group tolerance, affording a broad range of substrate scopes of up to 89% isolated yield. Diverse derivatization of the 2-azo-benzonitrile product resulted in other valuable scaffolds.

Synthesis, antiprotozoal activity, and cheminformatic analysis of 2-phenyl-2h-indazole derivatives

Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties. Particularly, the antiprotozoal activity of indazole derivatives have been recently reported. Herein, a series of 22 indazole derivatives was synthesized and studied as antiprotozoals. The 2-phenyl-2H-indazole scaffold was accessed by a one-pot procedure, which includes a combination of ultrasound synthesis under neat conditions as well as Cadogan’s cyclization. Moreover, some compounds were derivatized to have an appropriate set to provide structure-activity relationships (SAR) information. Whereas the antiprotozoal activity of six of these compounds against E. histolytica, G. intestinalis, and T. vaginalis had been previously reported, the activity of the additional 16 compounds was evaluated against these same protozoa. The biological assays revealed structural features that favor the antiprotozoal activity against the three protozoans tested, e.g., electron withdrawing groups at the 2-phenyl ring. It is important to mention that the indazole derivatives possess strong antiprotozoal activity and are also characterized by a continuous SAR.

New yellow-emitting iridium(III) complexes containing 2-phenyl-2H-indazole-based ligands for high efficient OLEDs with EQE over 25%

Six new pidz-based bis-cyclometalated Ir(III) complexes (Ir1-Ir6) have been synthesized and characterized. These complexes contain 2-phenyl-2H-indazole (pidz, 2a), 2-(4-fluorophenyl)–2H-indazole (fpidz, 2b), 2-(p-tolyl)–2H-indazole (ch3pidz, 2c), 2-(4-(trifluoromethyl)phenyl)–2H-indazole (cf3pidz, 2d), 2-(2,4-difluorophenyl)–2H-indazole (2,4-f2pidz, 2e) and 2-(3,5-difluorophenyl)–2H-indazole (3,5-f2pidz, 2f) as cyclometalated (C∧N) ligands, and acetylacetone (acacH) as ancillary ligand. The crystal structure of Ir2 has been determined by X-ray analysis. Different substituents of C∧N ligand in Ir2-Ir6 induce either a bathochromic or hypsochromic shift in the absorption spectra relative to the parent complex Ir1. The phenomenon is further well explained by DFT calculation and electrochemical study. All of the iridium(III) complexes are yellow emissive with quantum yields of 13.1–32.3% and lifetimes of 1.32–1.77 μs in solution at room temperature. We demonstrate that their emission originates from a hybrid 3MLCT/3ILCT/3LLCT excited state on the basis of the experimental and theoretical investigation. The corresponding yellow-emitting devices based on complexes Ir1, Ir2 and Ir4 can produce efficient electrophosphorescence with a luminance efficiency of 35.1–52.2 cd·A-1, a power efficiency of 20.8–32.1 lm·W?1 and an external quantum efficiency of up to 25.6%. All these EL data definitely suggest the bulky –CF3 skeleton in the doped materials could benefit the fabrication of high-efficiency phosphorescent OLEDs.

Tunable Emission Color of Iridium(III) Complexes with Phenylpyrazole Derivatives as the Main Ligands for Organic Light-Emitting Diodes

Seven cyclometalated iridium(III) complexes Ir1-Ir7 based on phenylpyrazole derivatives as main ligands and tetraphenylimidodiphosphinate (tpip) as the ancillary ligand were synthesized and fully characterized. The proligands of 1-[4-(trifluoromethyl)phenyl]-1H-pyrazole (cf3ppz, 2a), substituted phenyl-2H-indazole {2-phenyl-2H-indazole (h-1-pidz, 2b), 2-(4-fluorophenyl)-2H-indazole (f-1-pidz, 2c), and 2-[4-(trifluoromethyl)phenyl]-2H-indazole (cf3-1-pidz, 2d)}, and substituted phenyl-1H-indazole {1-phenyl-1H-indazole (h-7-pidz, 2e), 1-(4-fluorophenyl)-1H-indazole (f-7-pidz, 2f), and 1-[4-(trifluoromethyl)phenyl]-1H-indazole (cf3-7-pidz, 2g)} were prepared with good yields. The emission maxima of all Ir(III) complexes can be tuned from 453 to 576 nm with different photoluminescence quantum yields (10.4-70.9%) by varying the type of substituent on the different main ligand frameworks. The organic light-emitting diodes using Ir(III) complexes as the emitters with blue, bluish-green, and yellow colors exhibit a maximum current efficiency and an external quantum efficiency of 39.2 cd A-1 and 14.8%, respectively.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.