39167-47-0

Upstream product

• 99-91-2 para-chloroacetophenone 
• 92609-97-7 selenoformamide 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 117375-03-8 3,4-Bis-(4-chloro-phenyl)-selenophene 
• 117375-00-5 (3R,4S)-3,4-Bis-(4-chloro-phenyl)-tetrahydro-selenophene-3,4-diol 
• 75416-78-3 4,4'-(buta-1,3-diene-2,3-diyl)bis(chlorobenzene) 
• 111289-30-6 [5-(4-Chloro-benzoyl)-selenophen-2-yl]-(4-chloro-phenyl)-methanone 
• 40338-35-0 3,6-bis-(4-chloro-phenyl)-2,7-dihydro-[1,4,5]selenadiazepine 

Relevant academic research and scientific papers

Synthesis of 2-unsubstituted 1,3-selenazoles by cyclization of selenoformamide with α-bromocarbonyl compounds

2-Unsubstituted 1,3-selenazoles were prepared by cyclization of selenoformamide with α-bromoacetophenones. Parent 1,3-selenazole was prepared by cyclization of selenoformamide with α-bromoacetaldehyde.

1,3-Selenazole

The parent 1,3-selenazole was prepared by cyclization of selenoformamide with α-bromoacetaldehyde. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

SYNTHESES WITH DIKETO SELENIDES

We report a) a modified synthesis of diketo selenides, b) preparation of 2,5-diacylselenophenes by condensation of diketoselenides with glyoxal, c) preparation of poly-substituted selenophenes by intramolecular reductive coupling reaction of diketo selenides with low-valent titanium reagent under controlled conditions (0 degC) followed by dehydratation of the resulting 3,4-dihydroxyselenolanes, and d) formation of 2,5-dihydroselenophenes and 1,3-dienes by treatment of diketo selenides with the low-valent titanium reagent in refluxing tetrahydrofuran.

PREPARATION OF 2,5-DIACYLSELENOPHENES BY CONDENSATION 0F α,α'-DIKETOSELENIDES WITH GLYOXAL

The reaction of selenium oxychloride with 2 equiv. of ketones affords α,α'-diketo selenide dichlorides (1) in excellent yields.Portionwise addition of 1 to a stirred two-phase mixture of an aqueous sodium dithionite solution and benzene gives α,α'-diketo