391680-60-7

Upstream product

• 129694-52-6 ethyl (Z)-N-(2-amino-1,2-dicyanovinyl)formamidate 
• 89-97-4 2-CHLOROBENZYLAMINE 

Downstream Products

• 108575-36-6 1-(2-chlorobenzyl)-5-amino-1H-imidazole-4-carbonitrile 
• 1220095-33-9 4-(1-(2-chlorobenzyl)-5-amino-1H-imidazol-4-yl)-1-(4-methoxybenzyl)-5-imino-1H-imidazol-2(5H)-one 
• 1261168-08-4 C₂₁H₁₉ClN₆O₂ 
• 1220095-25-9 3,7-dihydro-3-[(4-methoxyphenyl)methyl]-7-[(2-chlorophenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one 

Relevant academic research and scientific papers

FUSED DIIMIDAZODIAZEPINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE THEREOF

The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also enc

Synthesis of aryl(or benzyl)-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidines

Starting from readily available ethyl(Z)-N-(2-amino-1,2-dicyanovinyl)formimidate (1), the N-aryl (or benzyl)-N′(-(2-amino-1,2-dicyanovinyl)formamidines (2) can be prepared in good yields by reaction with aromatic amines at room temperature in the presence of a catalytic amount of aniline hydrochloride.

Synthesis of aryl(orbenzyl)-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidines

Starting from readily available ethyl(Z)-N-(2-amino-1,2-dicyanovinyl)formimidate (1), the N-aryl (or benzyl)-N′-(2-amino-1,2-dicyanovinyl)formamidines (2) can be prepared in good yields by reaction with aromatic amines at room temperature in the presence of a catalytic amount of anilinium hydrochloride.

Synthesis of 5-amino-1-aryl-4-cyanoimidazoles from N-aryl-N′-(1,2-dicyanovinyl)-formamidines

The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine cyclize in the presence of base to give a 1,5-diamino-4-cyanoimidazole or a 1,5-diamino-4-(cyanoformimidoyl)imidazole, depending on the reaction conditions and the nature of the base used to induced cyc