391688-77-0

Basic information

• Product Name: ethyl 2-(6,7-dimethyl-2-oxo-4-phenyl-2H-chromen-3-yl)acetate
• CAS NO: 391688-77-0
• Molecular Weight: 336.387
• Mol File: 391688-77-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(6,7-dimethyl-2-oxo-4-phenyl-2H-chromen-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(6,7-dimethyl-2-oxo-4-phenyl-2H-chromen-3-yl)acetate(391688-77-0)
• EPA Substance Registry System: ethyl 2-(6,7-dimethyl-2-oxo-4-phenyl-2H-chromen-3-yl)acetate(391688-77-0)

Safety Data

• Hazardous Substances Data: 391688-77-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 4072-14-4 (4,5-dimethyl-2-hydroxyphenyl)(phenyl)methanone 
• 95-65-8 3,4-Dimethylphenol 

Relevant articles and documents

Discovery of a potent and orally available acyl-CoA: Cholesterol acyltransferase inhibitor as an anti-atherosclerotic agent: (4-Phenylcoumarin) acetanilide derivatives

Acyl-CoA: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes cholesterol esterification. ACAT inhibitors are expected to be potent therapeutic agents for the treatment of atherosclerosis. A series of potent ACAT inhibitors based on an (4-phenylcoumarin)acetanilide scaffold was identified. Evaluation of the structure-activity relationships of a substituent on this scaffold, with an emphasis on improving the pharmacokinetic profile led to the discovery of 2-[7-chloro-4-(3-chlorophenyl)-6-methyl-2-oxo-2H-chromen-3- yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (23), which exhibited potent ACAT inhibitory activity (IC50=12 nM) and good pharmacokinetic profile in mice. Compound 23 also showed regressive effects on atherosclerotic plaques in apolipoprotein (apo)E knock out (KO) mice at a dose of 0.3 mg/kg per os ( p.o.).