39180-36-4

Usage

InChI:InChI=1/C14H11NO4/c1-19-14(16)11-7-8-12(13(9-11)15(17)18)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 89976-27-2 methyl ester of 4-iodo-3-nitrobenzoic acid 
• 98-80-6 phenylboronic acid 
• 99-42-3 methyl (4-hydroxy-3-nitro)benzoate 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 123027-96-3 3-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester 
• 934-56-5 trimethyl(phenyl)stannane 
• 591-50-4 iodobenzene 
• 2363-16-8 methyl 4-bromo-3-nitrobenzoate 

Downstream Products

• 26000-33-9 methyl 9H-carbazole-2-carboxylate 
• 815632-40-7 methyl 9-phenyl-9H-carbazole-2-carboxylate 
• 86439-57-8 9-methyl-9H-carbazol-2-amine 
• 4539-51-9 2-aminocarbazole 
• 51094-28-1 9H-carbazole-2-carboxylic acid 
• 483370-17-8 2-[(3,5-bis-trifluoromethyl-benzoyl)-methyl-amino]-biphenyl-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

Synthesize, characterization and application of phosphine-free polymer supported palladium nanoparticles as effective catalyst in Suzuki-Miyaura cross-coupling reactions

Heterogeneous catalysts were developed by supporting palladium nanoparticles on modified cross-linked polyacrylamide and successfully applied in Suzuki-Miyaura cross-coupling reactions. These catalysts are stable to air and moisture, and no sign of metal leaching was detected during the reactions as judged by elemental analysis of palladiumby ICP-OES technique and hot filtration test, which demonstrates the heterogeneous character of the catalysts. High yields of desired products were resulted by using these phosphine- free catalysts at temperatures below 80 °C without aid of any additional ligands. The heat stability of the catalysts at the operating temperature was confirmed by thermogravimetric analysis (TGA). These catalysts are easy to use and cost effective. They can be recovered fromreaction mixture by a simple filtration and reused in more successive reactions without significant loss in activity. The catalyst activity was restored by an ultrasonication program after deactivation in 10 cycles.

ACYLGUANIDINE DERIVATIVE

An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia and the like, based on the 5-HT5A receptor modulating action. It was confirmed that a compound characterized by a st

ACYLGUANIDINE DERIVATIVE OR SALT THEREOF

[Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which S-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or preven

Triphenylphosphine-mediated reductive cyclization of 2-nitrobiphenyls: A practical and convenient synthesis of carbazoles

The synthesis of a series of substituted carbazoles from the corresponding 2-nitrobiphenyl derivatives using a novel modification of the Cadogan reaction is described. Cyclization of the 2-nitrobiphenyls was achieved via reductive deoxygenation of the nitro groups using a slight excess of triphenylphosphine in a suitable solvent. We have observed a temperature dependence on the extent of conversion under these conditions, with higher boiling solvents affording higher yields across a range of substrates. The new reaction conditions are very straightforward and convenient to execute, tolerate a broad range of functional groups, and yield carbazole products in the absence of unwanted side products.

Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.

In a continuation of our efforts to simplify the structure of our neurokinin antagonists, a series of substituted biphenyl derivatives has been prepared. Several compounds exhibit potent affinities for both the NK(1) receptor (10nM) and for the NK(2) rec

Stille and suzuki cross coupling reactions of o-nitrophenyl triflates: A versatile route to a variety of heterocycles

The cross coupling reactions of selected o-nitrophenyl triflates with arylstannane and arylboron substrates are reported. The resultant 2-nitrobiphenyls provide ready access to a variety of substituted heterocycles.