391888-88-3

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-
• CAS NO: 391888-88-3
• Molecular Formula: C36H36F3NO3S
• Molecular Weight: 619.748
• Mol File: 391888-88-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-(391888-88-3)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-(391888-88-3)

Safety Data

• Hazardous Substances Data: 391888-88-3(Hazardous Substances Data)

Upstream product

• 169032-99-9 (2S,4S)-4-Chloro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 176306-17-5 (2S,4R)-4-tritylsulfanylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl-2-methyl diester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 157911-56-3 2,4,5-trifluorobenzyl bromide 
• 337307-10-5 (2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 844476-69-3 (2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2,3-dihydrobenzo[1,4]dioxin-5-yl ester 
• 393792-62-6 (2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester 
• 391889-21-7 (2S,4R)-5-propyl-2-[2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidin-1-yl]pyrimidine 
• 844476-70-6 (2S,4R)-4-mercapto-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2,3-dihydrobenzo[1,4]dioxin-5-yl ester 
• 393789-23-6 (2S,4R)-4-mercapto-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester 
• 391888-89-4 (2S,4R)-2-(2,4,5-Trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidine 

Relevant articles and documents

Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells

Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1 a-d (ECE-1a-d; EC 3.4.24.71) represents another approach to block the ET-1 effect in cancer. To evaluate this potential, we synthesized and characterized a series of low nanomolar nonpeptidic thiol-containing ECE-1 inhibitors, and evaluated their effect, as well as the effect of inhibitors for the related metalloproteases neprilysin (NEP; EC 3.4.24.11) and angiotensin-converting enzyme (ACE; EC 3.4.15.1), on human glioblastoma cell growth. Only ECE-1 inhibitors inhibited DNA synthesis by human glioblastoma cells. Exogenous addition of ET-1 or bigET-1 to glioblastoma cells did not counterbalance the growth inhibition elicited by ECE-1 inhibitors, suggesting that ECE-1 inhibitors block the proliferation of human glioblastoma cells most likely via a mechanism not involving extracellular production of ET-1. This class of molecules may thus represent novel therapeutic agents for the potential treatment of human cancer.