1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-
CAS No.:391888-88-3
Molecular Formula:C36H36F3NO3S
Molecular Weight:619.748
Hs Code.:
Mol file:391888-88-3.mol

1-Pyrrolidinecarboxylic acid,
2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-,
1,1-dimethylethyl ester, (2S,4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-

Chemical Property:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)-

There total 4 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 157911-56-3
2,4,5-trifluorobenzyl bromide

: 337307-10-5
(2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 391888-88-3
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm040857x

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 391888-88-3
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / CCl₄; PPh₃ / CH₂Cl₂ / 4 h / 3 - 35 °C

2.1: KO-t-Bu / dimethylformamide / 0.33 h / 20 °C

2.2: 83 percent / dimethylformamide / 3.25 h / 0 - 20 °C

3.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

4.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

With tetrachloromethane; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x

Reference yield:

: 176306-17-5
(2S,4R)-4-tritylsulfanylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl-2-methyl diester

: 391888-88-3
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

2: 70 percent / NaH / dimethylformamide / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x