39192-49-9

Basic information

• Product Name: Benzoyl chloride, 3,5-bis(acetyloxy)-
• CAS NO: 39192-49-9
• Molecular Formula: C11H9ClO5
• Molecular Weight: 256.642
• Mol File: 39192-49-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 3,5-bis(acetyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 3,5-bis(acetyloxy)-(39192-49-9)
• EPA Substance Registry System: Benzoyl chloride, 3,5-bis(acetyloxy)-(39192-49-9)

Safety Data

• Hazardous Substances Data: 39192-49-9(Hazardous Substances Data)

Upstream product

• 35354-29-1 3,5-diacetoxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 

Downstream Products

• 61227-18-7 3,5-diacetoxybenzamide 
• 57179-37-0 3,5-diacetoxybenzaldehyde 
• 501-36-0 resveratrol 
• 1236211-47-4 resveratrol trimethacrylate 
• 60081-19-8 1,3-diacetoxy-5-(1,3-dithiolan-2-yl)benzene 
• 35154-48-4 3,3',4',5,5'-pentahydroxystilbene 

Relevant articles and documents

Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents

A series of S-allyl-L-cysteine (SAC) with garlic acid conjugates as anti-inflammatory agents were designed and synthesized. Among the 40 tested compounds, SMU-8c exhibited the most potent inhibitory activity to Pam3CSK4-induced nitric oxide (NO) in RAW264.7 macrophages with IC50 of 22.54 ± 2.60 μM. The structure-activity relationship (SAR) study suggested that the esterified carboxyl group, carbon chain extension and methoxylation phenol hydroxy could improve the anti-inflammatory efficacy. Preliminary anti-inflammatory mechanism studies showed that SMU-8c significantly down-regulated the levels of Pam3CSK4 triggered TNF-α cytokine in human THP-1 cells, mouse RAW 264.7 macrophages, as well as in ex-vivo human peripheral blood mononuclear cells (PBMC) with no influence on cell viability. SMU-8c specifically blocked the Pam3CSK4 ignited secreted embryonic alkaline phosphatase (SEAP) signaling with no influence to Poly I:C or LPS triggered TLR3 or TLR4 signaling. Moreover, SMU-8c suppressed TLR2 in HEK-Blue hTLR2 cells and inhibited the formation of TLR1-TLR2, and TLR2-TLR6 complex in human PBMC. In summary, SMU-8c inhibited the TLR2 signaling pathway to down-regulate the inflammation cytokines, such as NO, SEAP and TNF-α, to realize its anti-inflammatory activity.

MOLECULARLY IMPRINTED POLYMERS

The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

PREPARATION METHOD OF ACYLBENZENES

A process for the production of acylbenzenes, comprising reacting diacetoxybenzoyl chloride with a Grignard reagent in the presence of an iron-containing catalyst. The acylbenzenes are useful intermediates in a multistep process for the preparation of resveratrol.