392-86-9 Usage
General Description
2-Aminobenzenesulphonyl fluoride, also known as benzenesulfonyl fluoride, is a chemical compound with the formula C6H6FNO2S. It is an organofluorine compound and a sulfonyl fluoride, which is commonly used as a reagent in organic synthesis. 2-Aminobenzenesulphonyl fluoride is a highly reactive compound due to the presence of the fluoride group, and it is commonly used as a precursor for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a protecting group for amines in organic synthesis and as a coupling reagent in peptide synthesis. In addition, it has been investigated for its potential use as an inhibitor for enzymes and as a substrate for the production of fluorinated polymers. However, it is important to handle 2-aminobenzenesulphonyl fluoride with caution due to its reactivity and toxic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 392-86-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 392-86:
(5*3)+(4*9)+(3*2)+(2*8)+(1*6)=79
79 % 10 = 9
So 392-86-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H6FNO2S/c7-11(9,10)6-4-2-1-3-5(6)8/h1-4H,8H2
392-86-9Relevant articles and documents
(Chlorosulfonyl)benzenesulfonyl Fluorides - Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
Tolmachova, Kateryna A.,Moroz, Yurii S.,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Borysko, Petro,Zozulya, Sergey,Gryniukova, Anastasia,Bogolubsky, Andrey V.,Pipko, Sergey,Mykhailiuk, Pavel K.,Brovarets, Volodymyr S.,Grygorenko, Oleksandr O.
, p. 672 - 680 (2018/11/23)
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.
