392-86-9 Usage
Uses
Used in Organic Synthesis:
2-Aminobenzenesulphonyl fluoride is used as a reagent in organic synthesis for its high reactivity, facilitating the formation of various chemical compounds.
Used in Pharmaceutical and Agrochemical Synthesis:
It serves as a precursor in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used as a Protecting Group for Amines:
In organic synthesis, 2-aminobenzenesulphonyl fluoride is used as a protecting group for amines, preventing unwanted reactions and ensuring the selective formation of desired products.
Used in Peptide Synthesis:
It functions as a coupling reagent in peptide synthesis, aiding in the formation of peptide bonds between amino acids to create larger peptide chains.
Used in Enzyme Inhibition:
2-Aminobenzenesulphonyl fluoride has been investigated for its potential use as an inhibitor for enzymes, which could have applications in the development of enzyme-targeting drugs.
Used in Fluorinated Polymer Production:
It is also considered as a substrate for the production of fluorinated polymers, which have unique properties and applications in various industries.
Used in Research and Development:
Due to its reactivity and potential applications, 2-aminobenzenesulphonyl fluoride is utilized in research and development for exploring new chemical reactions and applications in various fields.
It is crucial to handle 2-aminobenzenesulphonyl fluoride with care due to its reactivity and toxic properties, ensuring safety in its use and application.
Check Digit Verification of cas no
The CAS Registry Mumber 392-86-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 392-86:
(5*3)+(4*9)+(3*2)+(2*8)+(1*6)=79
79 % 10 = 9
So 392-86-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H6FNO2S/c7-11(9,10)6-4-2-1-3-5(6)8/h1-4H,8H2
392-86-9Relevant academic research and scientific papers
(Chlorosulfonyl)benzenesulfonyl Fluorides - Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
Tolmachova, Kateryna A.,Moroz, Yurii S.,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Borysko, Petro,Zozulya, Sergey,Gryniukova, Anastasia,Bogolubsky, Andrey V.,Pipko, Sergey,Mykhailiuk, Pavel K.,Brovarets, Volodymyr S.,Grygorenko, Oleksandr O.
, p. 672 - 680 (2018/11/23)
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.
