39200-73-2Relevant articles and documents
Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-κB Inhibitors and Cytotoxic Agents
Jo, Hyeju,Choi, Minho,Kumar, Arepalli Sateesh,Jung, Yeongeun,Kim, Sangeun,Yun, Jieun,Kang, Jong-Soon,Kim, Youngsoo,Han, Sang-Bae,Jung, Jae-Kyung,Cho, Jungsook,Lee, Kiho,Kwak, Jae-Hwan,Lee, Heesoon
supporting information, p. 385 - 390 (2016/05/19)
1,2,3,4-Tetrahydroquinolines have been identified as the most potent inhibitors of LPS-induced NF-κB transcriptional activity. To discover new molecules of this class with excellent activities, we designed and synthesized a series of novel derivatives of 1,2,3,4-tetrahydroquinolines (4a-g, 5a-h, 6a-h, and 7a-h) and bioevaluated their in vitro activity against human cancer cell lines (NCI-H23, ACHN, MDA-MB-231, PC-3, NUGC-3, and HCT 15). Among all synthesized scaffolds, 6g exhibited the most potent inhibition (53 times that of a reference compound) of LPS-induced NF-κB transcriptional activity and the most potent cytotoxicity against all evaluated human cancer cell lines.
Investigating the spectrum of biological activity of substituted quinoline-2-carboxamides and their isosteres
Gonec, Tomas,Bobal, Pavel,Sujan, Josef,Pesko, Matus,Guo, Jiahui,Kralova, Katarina,Pavlacka, Lenka,Vesely, Libor,Kreckova, Eva,Kos, Jiri,Coffey, Aidan,Kollar, Peter,Imramovsky, Ales,Placek, Lukas,Jampilek, Josef
, p. 613 - 644 (2012/03/09)
In this study, a series of thirty-five substituted quinoline-2-carboxamides and thirty-three substituted naphthalene-2-carboxamides were prepared and characterized. They were tested for their activity related to the inhibition of photosynthetic electron t
