39200-73-2Relevant academic research and scientific papers
Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-κB Inhibitors and Cytotoxic Agents
Jo, Hyeju,Choi, Minho,Kumar, Arepalli Sateesh,Jung, Yeongeun,Kim, Sangeun,Yun, Jieun,Kang, Jong-Soon,Kim, Youngsoo,Han, Sang-Bae,Jung, Jae-Kyung,Cho, Jungsook,Lee, Kiho,Kwak, Jae-Hwan,Lee, Heesoon
supporting information, p. 385 - 390 (2016/05/19)
1,2,3,4-Tetrahydroquinolines have been identified as the most potent inhibitors of LPS-induced NF-κB transcriptional activity. To discover new molecules of this class with excellent activities, we designed and synthesized a series of novel derivatives of 1,2,3,4-tetrahydroquinolines (4a-g, 5a-h, 6a-h, and 7a-h) and bioevaluated their in vitro activity against human cancer cell lines (NCI-H23, ACHN, MDA-MB-231, PC-3, NUGC-3, and HCT 15). Among all synthesized scaffolds, 6g exhibited the most potent inhibition (53 times that of a reference compound) of LPS-induced NF-κB transcriptional activity and the most potent cytotoxicity against all evaluated human cancer cell lines.
Novel method of synthesizing various five membered heterocycles from an aryl tribromomethyl group
Tynebor, Robert,Millings, Elizabeth
, p. 1902 - 1908 (2013/05/21)
Synthesis of five membered heterocycles from an aryl tribromomethyl functional group is discussed. Exposing a tribromomethyl group to subsequent nucleophilic attacks by a 1,2-di-nucleophilic species promotes the cyclization of five membered heterocycles. Such heterocycles as oxadiazoles, thiadiazole, benzimidazole, benzothioazole, and benzoxazole were synthesized in moderate to good yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
Investigating the spectrum of biological activity of substituted quinoline-2-carboxamides and their isosteres
Gonec, Tomas,Bobal, Pavel,Sujan, Josef,Pesko, Matus,Guo, Jiahui,Kralova, Katarina,Pavlacka, Lenka,Vesely, Libor,Kreckova, Eva,Kos, Jiri,Coffey, Aidan,Kollar, Peter,Imramovsky, Ales,Placek, Lukas,Jampilek, Josef
, p. 613 - 644 (2012/03/09)
In this study, a series of thirty-five substituted quinoline-2-carboxamides and thirty-three substituted naphthalene-2-carboxamides were prepared and characterized. They were tested for their activity related to the inhibition of photosynthetic electron t
