39203-59-3Relevant academic research and scientific papers
Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines
Chen, Yan,Shatskiy, Andrey,Liu, Jian-Quan,K?rk?s, Markus D.,Wang, Xiang-Shan
, p. 7555 - 7560 (2021/10/02)
An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.
Method for synthesizing indolizine compound under catalysis of silver
-
Paragraph 0033-0037; 0092-0107, (2021/08/06)
The invention discloses a method for synthesizing indolizine compounds under the catalysis of silver, which comprises the following steps of in an organic solvent system, stirring N-benzoylmethyl pyridinium bromide as shown in a formula (1) and an isocyanide compound as shown in a formula (2) according to a feeding molar ratio of 1: (1.2-2.0) in the presence of a metal silver salt as a catalyst to react in the air under an alkaline condition, and carrying out TLC tracking detection until the reaction is complete, and carrying out post-treatment on the reaction liquid to obtain the indolizine compound as shown in a formula (3). The method is easy to operate, raw materials and reagents are easy to obtain, reaction conditions are mild, a reaction system is environmentally friendly, products are easy to separate and purify, the yield reaches up to 91%, and the method is suitable for efficient and high-yield preparation of indolizine compounds and particularly suitable for synthesis of various 1, 2-substituted indolizine compounds. The method is suitable for large-scale industrial production, and has wide application prospects and important significance in organic synthesis.
Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids
Yang, Yuzhu,Xie, Chunsong,Xie, Yongju,Zhang, Yuhong
supporting information; experimental part, p. 957 - 959 (2012/04/04)
A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.
Novel syntheses of indolizines and pyrrolo[2,1-a]isoquinolines via benzotriazole methodology
Katritzky, Alan R.,Qiu, Guofang,Yang, Baozhen,He, Hai-Ying
, p. 7618 - 7621 (2007/10/03)
Indolizines and pyrrolo[2,1-a]isoquinolines are synthesized by 1,3- dipolar cycloadditions of pyridinium benzotriazolylmethylides or isoquinolinium benzotriazolylmethylides with ethylenes and acetylenes.
Lactone compounds containing an indolizine radical
-
, (2008/06/13)
Chromogenic compounds of normally colorless form are disclosed having the following structural formula: STR1 wherein E represents a six-membered aromatic or heterocyclic ring which may have an aromatic ring or a naphthalene ring and both the E ring and th
