ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE
• CAS No.: 39203-59-3
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol file: 39203-59-3.mol

Synonyms:1-carboethoxy-2-phenylindolizine;ethyl 2-phenylindolizine-3-carboxylate;ethyl 2-phenylindolizine-1-carboxylate;2-phenylindolizine-1-carboxylic acid ethyl ester;2-phenyl-indolizine-1-carboxylic acid ethyl ester;

Chemical Property of ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE

Chemical Property:

• PSA: 30.71000
• LogP: 3.78300

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-phenyl-1-indolizinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE

There total 11 articles about ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Ethyl isocyanoacetate (2999-46-4) + N-phenacylpyridinium bromide (16883-69-5) → ethyl 2-phenyl-1-indolizinecarboxylate (39203-59-3)

Guidance literature:

With triethylamine; silver carbonate; In 1,4-dioxane; at 25 ℃; for 10h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02754

Reference yield: 80.7%

ethyl-2-pyridine acetate + diethyl ether (60-29-7,927820-24-4) + α-bromoacetophenone (70-11-1) → ethyl 2-phenyl-1-indolizinecarboxylate (39203-59-3)

Guidance literature:

With hydrogenchloride; In acetone;

Reference yield: 59.0%

1-[(benzotriazol-1-yl)methyl]pyridinium chloride (111198-06-2) + phenylpropynoic acid ethyl ester (2216-94-6) → ethyl 2-phenyl-1-indolizinecarboxylate (39203-59-3)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 20h;

DOI:10.1021/jo9906936

upstream raw materials:

1-[(benzotriazol-1-yl)methyl]pyridinium chloride

phenylpropynoic acid ethyl ester

pyridine

diethyl ether

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