39216-18-7Relevant academic research and scientific papers
Reaction of 1,3-dicarbonyl compounds with o-phenylenediamine or 3,3′-diaminobenzidine in water or under solvent-free conditions via microwave irradiation
Wang, Zhong-Xia,Qin, Hua-Li
, p. 1001 - 1005 (2007/10/03)
Reaction of o-phenylenediamine with β-diketones or β-ketoesters in water formed 2-substituted benzimidazoles. Reaction of 3,3′- diaminobenzidine gave similar results. Under microwave irradiation conditions solvent-free reaction of o-phenylenediamine with β-ketoesters afforded 1,5-benzodiazepin-2-one derivatives. An exception is the reaction of o-phenylenediamine with ethyl acetoacetate under microwave irradiation, which gave 2-methylbenzimidazole.
Synthesis and Biological Activity of Novel Calcium Channel Blockers: 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic Acid Esters and 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic Acid Esters
Atwal, Karnail S.,Bergey, James L.,Hedberg, Anders,Moreland, Suzanne
, p. 635 - 640 (2007/10/02)
2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters, based on the structures of dihydropyridines and diltiazem, were synthesized from o-aminothiophenol and 2-(phenylmethylene)-3-oxobutanoic acid esters.Biological evaluation in the p
