39250-16-3Relevant academic research and scientific papers
Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors
Kulikov, Alexander S.,Epishina, Margarita A.,Zhilin, Egor S.,Shuvaev, Alexander D.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 42 - 45 (2021/02/16)
A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.
Method of treating animals and formulations therefor
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, (2008/06/13)
This invention relates to a new method of using and formulations of pyruvoyl chloride phenylhydrazones of the formula SPC1 Wherein Y is selected from the group consisting of chloro, bromo, nitro and trifluoromethyl and Y' has the same meaning as Y and in addition hydrogen, that have been found to be effective broad spectrum anthelmintics for suppressing parasitic worms in animals. The compounds are readily prepared by conventional chemical reactions.
