39254-87-0

Upstream product

• 161988-57-4 2-formamidophenyl-2'-thiazolylketone 
• 39264-15-8 (2-nitrophenyl)-(2-thiazolyl)methanol 
• 610-14-0 2-nitrobenzyl chloride 
• 552-89-6 2-nitro-benzaldehyde 
• 39264-16-9 2-nitrophenyl-2'-thiazolylketone 
• 135531-86-1 camalexin 

Downstream Products

• 161988-57-4 2-formamidophenyl-2'-thiazolylketone 
• 39481-64-6 [2-(2-bromo-acetylamino)-5-iodo-phenyl]-thiazol-2-yl-methanone 
• 135531-86-1 camalexin 
• 168161-79-3 [1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-thiazol-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 168161-78-2 (2-Oxo-5-thiazol-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester 
• 39254-78-9 (2-amino-5-iodo-phenyl)-thiazol-2-yl-methanone 
• 39264-18-1 [2-(2-bromo-acetylamino)-phenyl]-thiazol-2-yl-methanone 

Relevant academic research and scientific papers

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Biotransformation of the phytoalexin camalexin by the phytopathogen Rhizoctonia solani

The unusual metabolism of the cruciferous phytoalexin camalexin by virulent and weakly virulent isolates of the root rot fungus Rhizoctonia solani Kuhn is reported. This biotransformation proceeded via 5- hydroxycamalexin, which was further biotransformed into more polar metabolites. Importantly, the metabolites resulting from transformation of camalexin were significantly less toxic to the pathogen than camalexin. Thus, it was concluded that R. solani can detoxify camalexin through oxidation of the indole ring. The chemistry involved in the structure determination of the intermediates of this pathway, their synthesis as well as antifungal activity is described.

Syntheses of Camalexin, Indolopyridocoline and Flavopereirine

A short synthetic route to the phytoalexin camalexin 7 and a convergent approach to the alkaloids indolopyridocoline 8, 6,7-dihydroflavopereirine 15 and flavopereirine 9 are presented.Starting from well accessible precursors, these total syntheses highlight the preparative potential of a new method for indole synthesis based on the formation of the C2-C3 bond by low-valent titanium induced reductive coupling of oxo-amides.