39272-00-9Relevant articles and documents
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors
Gobbi, Silvia,Cavalli, Andrea,Negri, Matthias,Schewe, Katarzyna E.,Belluti, Federica,Piazzi, Lorna,Hartmann, Rolf W.,Recanatini, Maurizio,Bisi, Alessandra
, p. 3420 - 3422 (2008/02/12)
Suppression of tumor and plasma estrogen levels by inhibition of aromatase is one of the most effective treatments for post-menopausal breast cancer patients. Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17α-hydroxylase/17,20-lyase (CYP17). Compounds 1b and 1d proved to be among the most potent inhibitors described so far.