439937-52-7

Usage

Uses

Used in Pharmaceutical Industry:
(5-Bromo-2-methylphenyl)(phenyl)methanone is used as an intermediate for the synthesis of various pharmaceuticals due to its ability to facilitate the creation of complex molecular structures. Its versatility in chemical reactions makes it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, (5-Bromo-2-methylphenyl)(phenyl)methanone is employed as a key intermediate in the production of various agrochemicals. Its role in the synthesis of these compounds contributes to the development of more effective and targeted pest control solutions.
Used in Fine Chemicals Production:
(5-Bromo-2-methylphenyl)(phenyl)methanone is used as an intermediate in the production of fine chemicals, which are high-purity chemicals used in various applications, such as fragrances, dyes, and specialty chemicals. Its involvement in the synthesis process helps to create high-quality and specialized products.
Used in Organic Reactions and Processes:
(5-Bromo-2-methylphenyl)(phenyl)methanone is used as a reactant in the development of different organic reactions and processes. Its participation in these reactions allows for the creation of new and innovative chemical pathways, leading to the discovery of novel compounds and materials.
Used in Aromatic Compounds and Heterocycles Preparation:
(5-Bromo-2-methylphenyl)(phenyl)methanone is utilized in the preparation of various aromatic compounds and heterocycles, which are important building blocks in the synthesis of complex organic molecules. Its role in this process highlights its importance in the field of organic chemistry and the development of new chemical entities.

Upstream product

• 802593-83-5 (5-amino-2-methylphenyl)phenylmethanone 
• 64688-68-2 2-methyl-5-nitrobenzoyl chloride 
• 108-86-1 bromobenzene 
• 106-38-7 para-bromotoluene 
• 98-88-4 benzoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 39272-00-9 (2-methyl-5-nitrophenyl)phenylmethanone 
• 1975-52-6 5-nitro-o-toluic acid 

Downstream Products

• 412299-83-3 4-bromo-2-(phenylcarbonyl)benzoic acid 
• 412299-71-9 5-methyl-3-phenylisobenzofuran-1(3H)-one 

Relevant academic research and scientific papers

Photoenolization/nucleophilic addition enables direct access to 3-alkyl-3-hydroxy-indolin-2-ones

A light-driven, catalyst- and additive-free photoenolization/nucleophilic addition reaction for the synthesis of 3-benzyl-3-hydroxyindolin-2-ones is presented. In this reaction, 2-methylbenzophenones undergo light-induced enolization process to afford hydroxy-o-quinodimethanes (hydroxy-o-QDMs), which are then immediately captured by the electrophilic isatins. The reaction utilizes green and clean light energy to realize the C–H activation of the inert benzyl position of 2-methylbenzophenones. This method tolerates a wide scope of substrates and provides concise access to a series of novel 3-benzyl-3-hydroxyindolin-2-ones with 60–99% yields.

Microwave-assisted facile and rapid friedel-crafts benzoylation of arenes catalyzed by bismuth trifluoromethanesulfonate

The catalytic activity of metal triflates was investigated in Friedel-Crafts benzoylation under microwave irradiation. Friedel-Crafts benzoylation with benzoyl chloride of a variety of arenes containing electron-rich and electron-poor rings using bismuth triflate under microwave irradiation is described. This method allows the preparation of aryl ketones under solventless conditions in good to excellent yields and short reaction time. Bismuth triflate was easily recovered and reused five times without significant loss of the catalytic activity.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors

Suppression of tumor and plasma estrogen levels by inhibition of aromatase is one of the most effective treatments for post-menopausal breast cancer patients. Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17α-hydroxylase/17,20-lyase (CYP17). Compounds 1b and 1d proved to be among the most potent inhibitors described so far.