3929-76-8

Upstream product

• 98-00-0 (2-furyl)methyl alcohol 
• 76-83-5 trityl chloride 
• 190725-02-1 (S)-2-Phenylsulfanyl-5-trityloxymethyl-2,5-dihydro-furan 
• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 
• 182957-26-2 (2R,3S)-5-Phenylsulfanyl-2-trityloxymethyl-tetrahydro-furan-3-ol 
• 183075-04-9 phenyl 2-deoxy-1-thio-D-erythro-pentofuranoside 
• 452-51-7 D-2-deoxyribose 
• 5964-41-0 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl-5-O-trityl)thymine 

Relevant academic research and scientific papers

Friedel–Crafts Alkylation with Carbenium Ions Generated by Electrochemical Oxidation of Stannylmethyl Ethers

The electrochemical activation of stannylmethyl ethers was exploited for Friedel–Crafts alkylation of arenes at near-neutral conditions. Single cell anodic oxidation of stannylmethyl ethers leads to oxonium ions which fragment to carbenium ions in the pre

Simple entry to 3'-substituted analogues of anti-HIV agent stavudine based on an anionic O --> C stannyl migration.

Reaction of 5'-O-protected derivatives of the anti-HIV agent stavudine (d4T) with LTMP was investigated with the aim to lithiate the vinylic hydrogens (H-3' and H-2'). When the lithiation of the 5'-O-tert-butyldiphenylsilyl derivative 5 was carried out in the presence of HMPA, an anionic silyl migration took place to give the 3'-C-silylated product 4a. The stannyl version of this reaction was found to be also possible, which has disclosed a highly simple entry to the d4T analogues variously substituted at the 3'-position by manipulating the 3'-C-stannyl d4T as a common intermediate.

Facile synthesis of 2',3'-unsaturated nucleosides from 2-deoxyribose

A straightforward approach for the synthesis of 2',3'-unsaturated nucleosides starting from 2-deoxyribose is described. This novel route involves two new methods; (1) preparation of 2-deoxy-1-thioribofuranoside by direct condensation of 2-deoxyribose and thiophenol, (2) formation of the nucleoside skeleton by the direct coupling of 2,3-unsaturated 1-thiopentofuranoside with pyrimidine bases.

New method of synthesis of D-ribose and D-lyxose

An attempt has been made to synthesize D-ribose from D-xylose using only commercial products and a minimum number of steps. D-xylose was transformed into pentenofuranoside which then was hydrolyzed. In the pyranose series, the unsaturated derivative could