3931-52-0Relevant academic research and scientific papers
N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines
Golubev, Pavel,Krasavin, Mikhail
, p. 3532 - 3536 (2018/08/29)
N-Isocyanodialkylamines are rare isocyanide surrogates for the Ugi-type reactions. To avoid problems with instability and the obnoxious smell of these reagents, we optimized and employed a convenient protocol for in situ dehydration of N,N-dialkyl-N′-formyl hydrazines to give the respective N-isocyanodialkylamines which were utilized in the reaction with indolenines and acetic acid. The reaction was demonstrated to give modest to excellent yields of products incorporating the N-isocyanodialkylamine but not the carboxylic acid component.
Cephalosporin derivatives
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, (2008/06/13)
7 α-formamido cephalosporin derivatives having a 3[N-(optionally substituted)aminothiopyridinium thiomethyl] substituent have anti-bacterial activity and are of use in anti-bacterial therapy. Processes for the preparation thereof and intermediates for use in these processes are also disclosed.
Amidrazones 13. A Convenient Method for the Preparation of 1-Alkyl-1-methylhydrazines
Smith, Richard F.,Brophy, Keith A.,Rodriguez, George,Dennis, Lisa A.,Ryan, William J.
, p. 183 - 188 (2007/10/02)
An efficient one-pot procedure for the preparation of 1-alkyl-1-methylhydrazines from methylhydrazine via base-promoted hydrolysis of 1-alkyl-3-amino-4,5-dihydro-1-methyl-1H-pyrazolium halides (3) is described.
AMIDRAZONES 10. STEVENS REARRANGEMENT OF 1-BENZYL AND 1-ALLYL-SUBSTITUTED-3-AMINO-4,5-DIHYDRO-1-PHENYL-1H-PYRAZOLIUM BROMIDES
Smith, Richard F.,Aquino, Christopher J.,Olson, Laurie A.,Galante, Julienne M.,Liptak, Stephen C.
, p. 5663 - 5666 (2007/10/02)
2-Benzyl-3-imino-1-phenylpyrazolidine (5a) and 2-allyl-3-imino-1-phenylpyrazolidine (5b) are obtained by the base-promoted rearrangement of the title compounds (4a and 4b).
