393186-08-8Relevant academic research and scientific papers
Benzoxazole compound and pharmaceutical composition containing the same
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, (2008/06/13)
The present invention is directed to a benzoxazole compound represented by the following formula (1): (wherein R1represents an alkyl group, a C6-10aryl-C1-8alkyl group, etc.; each of R2and R3, which a
Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis
Liu, Kevin G,Lambert, Millard H,Leesnitzer, Lisa M,Oliver Jr., William,Ott, Ronda J,Plunket, Kelli D,Stuart, Ludwig W,Brown, Peter J,Willson, Timothy M,Sternbach, Daniel D
, p. 2959 - 2962 (2007/10/03)
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPARγ/δ dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyp
