91687-71-7Relevant academic research and scientific papers
Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis
Liu, Kevin G,Lambert, Millard H,Leesnitzer, Lisa M,Oliver Jr., William,Ott, Ronda J,Plunket, Kelli D,Stuart, Ludwig W,Brown, Peter J,Willson, Timothy M,Sternbach, Daniel D
, p. 2959 - 2962 (2001)
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPARγ/δ dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyp
HPPARS ACTIVATORS
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Page/Page column 21, (2010/02/07)
Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions a
