393511-89-2

Upstream product

• 259263-96-2 4-hydroxyphenethylamino-4-nitroanilinomethanone 
• 51-67-2 tyrosamine 
• 100-28-7 4-Nitrophenyl isocyanate 

Downstream Products

• 393511-88-1 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 
• 393511-90-5 1-{4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-3-[2-(4-hydroxy-phenyl)-ethyl]-urea 

Relevant academic research and scientific papers

Phenylethylamine derivatives and their use in the treatment of melanoma

Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, Ra is hydrogen or —COORb, Rb is hydrogen or C1-6 alkyl;

Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).

The suitability of 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 2 to act as a prodrug for melanocyte-directed enzyme prodrug therapy (MDEPT) is assessed. Thus its synthesis, ability to generate a cytotoxic agent upon exposure to tyrosinase, and stability within different sera are reported. A comparison is made to illustrate that the new urea prodrug 2 is a more suitable candidate for MDEPT than the corresponding carbamate prodrug 1.