393860-84-9Relevant academic research and scientific papers
Development of a functionalizable external β-turn mimic based on a cis-fused 1,7-naphthyridine scaffold
Rombouts, Frederik J. R.,De Borggraeve, Wim M.,Delaere, David,Froeyen, Matheus,Toppet, Suzanne M.,Compernolle, Frans,Hoornaert, Georges J.
, p. 1868 - 1878 (2007/10/03)
An intramolecular Diels-Alder strategy using 2(1H)-pyrazinones was applied to generate a substituted perhydro-1,7-naphthyridine ring system that served as a scaffold to construct the type VI β-turn mimic 2, featuring a cis-amide linkage between the centra
Intramolecular Diels-Alder reactions of N-alkenyl-2(1H)-pyrazinones: Generation of a novel type of cis-1,7-naphthyridine
Rombouts, Frederik J.R,De Borggraeve, Wim,Toppet, Suzanne M,Compernolle, Frans,Hoornaert, Georges J
, p. 7397 - 7399 (2007/10/03)
The intramolecular Diels-Alder reaction of three 1-(ω-alkenyl)-2(1H)-pyrazinones was investigated. Cycloaddition was shown to proceed for 1-(4-pentenyl)- and 1-(5-hexenyl)-2(1H)-pyrazinone 5a and 5b to give the corresponding tricyclic hydrolysed adducts 7
