102653-50-9

Basic information

• Product Name: 2(1H)-Pyrazinone, 5-chloro-3-phenyl-
• CAS NO: 102653-50-9
• Molecular Formula: C10H7ClN2O
• Molecular Weight: 206.631
• Mol File: 102653-50-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrazinone, 5-chloro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 5-chloro-3-phenyl-(102653-50-9)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 5-chloro-3-phenyl-(102653-50-9)

Safety Data

• Hazardous Substances Data: 102653-50-9(Hazardous Substances Data)

Upstream product

• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 98-80-6 phenylboronic acid 
• 100-34-5 benzene diazonium chloride 
• 99073-52-6 5-nitro-3-phenyl-1H-pyrazin-2-one 
• 99984-69-7 3-methoxy-2-phenyl-pyrazine-1-oxide 
• 98993-82-9 5-bromo-3-phenyl-1H-pyrazin-2-one 
• 64163-09-3 2,5-dichloro-6-phenylpyrazine 
• 99984-63-1 2-methoxy-3-phenylpyrazine 
• 41270-65-9 2-chloro-3-phenylpyrazine 
• 2882-18-0 3-phenyl-2(1H)-pyrazinone 
• 105985-16-8 2-amino-N-hydroxy-2-phenyl-acetamide 
• 393860-83-8 5-chloro-1-(4-methoxybenzyl)-3-phenylpyrazin-2-(1H)-one 
• 105985-15-7 1-hydroxy-3-phenyl-2(1H)-pyrazinone 

Downstream Products

• 74134-66-0 5-chloro-3,6-diphenyl-1H-pyrazin-2-one 
• 393860-85-0 1-(4-hexenyl)-2(1H)-pyrazinone 
• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 
• 100142-71-0 2,5-dimethoxy-3-phenyl-pyrazine 
• 98948-89-1 3-bromo-5-chloro-6-phenyl-1H-pyrazin-2-one 
• 393860-84-9 5-chloro-1-(4-pentenyl)-3-phenyl-2(1H)-pyrazinone 
• 64163-09-3 2,5-dichloro-6-phenylpyrazine 

Relevant articles and documents

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents

To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a–8c with similar EC50 values (0.20–0.22 μM) comparative to that of sofosbuvir (EC50 = 0.18 μM) in a genotype 1b based replicon Huh-7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC50 = 7.3 μM) and S-29b (EC50 = 19.5 μM). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.

Development of a functionalizable external β-turn mimic based on a cis-fused 1,7-naphthyridine scaffold

An intramolecular Diels-Alder strategy using 2(1H)-pyrazinones was applied to generate a substituted perhydro-1,7-naphthyridine ring system that served as a scaffold to construct the type VI β-turn mimic 2, featuring a cis-amide linkage between the centra

Studies on Pyrazines. 13. Chlorination of 1-Hydroxy-2(1H)-pyrazinones with Phosphoryl Chloride. Formation of 2,5-Dichloro-3-phenylpyrazine from 1-Hydroxy-3-phenyl-2(1H)-pyrazinone

The chlorination of 1-hydroxy-3-phenyl-2(1H)-pyrazinone with phosphoryl chloride proceeded to 5-chloro-3-phenyl-2(H)-pyrazinone or 2,5-dichloro-3-phenylpyrazine on heating to elevated temperatures.To define the mechanism of the novel formation, reactions