394-21-8

Basic information

• Product Name: 1-fluorophenazine
• CAS NO: 394-21-8
• Molecular Formula: C₁₂H₇FN₂
• Molecular Weight: 198.1958
• Mol File: 394-21-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 360.6°C at 760 mmHg
• Flash Point: 171.9°C
• Density: 1.336g/cm³
• Vapor Pressure: 4.55E-05mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 1-fluorophenazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluorophenazine(394-21-8)
• EPA Substance Registry System: 1-fluorophenazine(394-21-8)

Safety Data

• Hazardous Substances Data: 394-21-8(Hazardous Substances Data)

Usage

Chemical classification

1-fluorophenazine is a phenazine derivative, which is a heterocyclic compound consisting of two benzene rings fused to a central nitrogen-containing ring.

Molecular structure

The addition of a fluorine atom to the phenazine molecule is the key structural feature that gives 1-fluorophenazine its unique properties.

Medicinal chemistry interest

1-fluorophenazine has potential biological activities, such as antimicrobial and antitumor properties, making it a compound of interest for the development of new drug candidates for various therapeutic applications.

Organic synthesis and material science applications

Due to its unique chemical structure and reactivity, 1-fluorophenazine has potential applications in organic synthesis and material science.

Versatility

1-fluorophenazine is a versatile compound with diverse potential uses in various scientific and industrial fields.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 98-95-3 nitrobenzene 

Relevant articles and documents

Reactivity and substituent effects in the cyclization of N-aryl-2-nitrosoanilines to phenazines

Reactivity of variously substituted N-aryl-2-nitrosoanilines in the reaction of cyclization leading to phenazine derivatives, carried out in the presence of N,O-bis(trimethylsilyl)acetamide (BSA), was estimated on the base of the observed reaction times. A strong opposite effect of substituents located at position para to the nitroso group and those located para to the amino group in the side ring was observed. Mechanistic explanation, based on the electronic properties of the substituents and their mesomeric effects, was presented. The usefulness of the obtained data for the designed syntheses of phenazines was exposed.