394202-97-2

Upstream product

• 394202-91-6 4-(3-Methoxyphenyl)-1-piperidineacetic Acid Hydrazide 
• 182621-24-5 1,4-dihydro-4-(3-isocyanatophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester 
• 394202-85-8 [4-(3-methoxy-phenyl)-piperidin-1-yl]-acetic acid methyl ester 
• 99329-55-2 4-(3-methoxyphenyl)piperidine 
• 21835-63-2 1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester 

Relevant academic research and scientific papers

Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: Bioisosteric urea replacements

Structure-activity studies around the urea linkage in BMS-193885 (4a) identified the cyanoguanidine moiety as an effective urea replacement in a series of dihydropyridine NPY Y1 receptor antagonists. In comparison to urea 4a (Ki=3.3

Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of oxadiazole, thiadiazole and thiadiazole oxide derivatives of dihydropyridines of Formula I. wherein B is with X being O, S or and X1 is O or S. As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.